Shahat Abdelaaty A, Alsaid Mansour S, Kotob Soheir E, Ahmed Hanaa H
Pharmacognosy Department, College of Pharmacy, King Saud University, Giza, Egypt E-mail :
Asian Pac J Cancer Prev. 2015;16(10):4303-10. doi: 10.7314/apjcp.2015.16.10.4303.
Rumex vesicarius is an edible herb distributed in Egypt and Saudi Arabia. The whole plant has significant value in folk medicine and it has been used to alleviate several diseases. Hepatocellular carcinoma (HCC), the major primary malignant tumor of the liver, is one of the most life-threatening human cancers. The goal of the current study was to explore the potent role of Rumex vesicarius extract against HCC induced in rats. Thirty adult male albino rats were divided into 3 groups: (I): Healthy animals received orally 0.9% normal saline and served as negative control group, (II): HCC group in which rats were orally administered N-nitrosodiethylamine NDEA, (III): HCC group treated orally with R. vesicarius extract in a dose of 400 mg/kg b.wt daily for two months. ALT and AST, ALP and γ-GT activities were estimated. CEA, AFP, AFU, GPC-3, Gp-73 and VEGF levels were quantified. Histopathological examination of liver tissue sections was also carried out. The results of the current study showed that the treatment of the HCC group with R. vesicarius extract reversed the significant increase in liver enzymes activity, CEA, AFP, AFU, glypican 3, golgi 73 and VEGF levels in serum as compared to HCC-untreated counterparts. In addition, the favorable impact of R. vesicarius treatment was evidenced by the marked improvement in the histopathological features of the liver of the treated group. In conclusion, the present experimental setting provided evidence for the significance of R. vesicarius as anticancer candidate with a promising anticancer potential against HCC. The powerful hepatoprotective properties, the potent antiangiogenic activity and the effective antiproliferative capacity are responsible for the anticancer effect of this plant.
刺酸模是一种分布于埃及和沙特阿拉伯的可食用草本植物。其全株在民间医学中具有重要价值，已被用于缓解多种疾病。肝细胞癌（HCC）是肝脏主要的原发性恶性肿瘤，是最危及生命的人类癌症之一。本研究的目的是探讨刺酸模提取物对大鼠诱导性肝癌的潜在作用。将30只成年雄性白化大鼠分为3组：（I）：健康动物口服0.9%生理盐水，作为阴性对照组；（II）：肝癌组，大鼠口服N-亚硝基二乙胺（NDEA）；（III）：肝癌组，每天口服400mg/kg体重的刺酸模提取物，持续两个月。测定谷丙转氨酶（ALT）、谷草转氨酶（AST）、碱性磷酸酶（ALP）和γ-谷氨酰转移酶（γ-GT）活性。定量癌胚抗原（CEA）、甲胎蛋白（AFP）、α-L-岩藻糖苷酶（AFU）、磷脂酰肌醇蛋白聚糖-3（GPC-3）、高尔基体蛋白73（Gp-73）和血管内皮生长因子（VEGF）水平。还对肝组织切片进行了组织病理学检查。本研究结果表明，与未治疗的肝癌组相比，用刺酸模提取物治疗肝癌组可逆转血清中肝酶活性、CEA、AFP、AFU、磷脂酰肌醇蛋白聚糖3、高尔基体73和VEGF水平的显著升高。此外，刺酸模治疗的有利影响通过治疗组肝脏组织病理学特征的显著改善得到证明。总之，本实验设置为刺酸模作为抗癌候选药物的重要性提供了证据，其对肝癌具有有前景的抗癌潜力。强大的肝脏保护特性、有效的抗血管生成活性和有效的抗增殖能力是该植物抗癌作用的原因。
