Supuran Claudiu T
Università degli Studi di Firenze, Dipartimento NEUROFARBA, Sezione di Scienze Farmaceutiche e Nutraceutiche , Via U. Schiff 6, I-50019 Sesto Fiorentino (Firenze) , Italy
Expert Opin Ther Pat. 2015;25(8):945-8. doi: 10.1517/13543776.2015.1053207. Epub 2015 Jun 1.
Nanoparticles based on poly(dimethylaminoethyl methacrylate)-b-poly(dimethylaminoethyl methacrylate-co-propylacrylic acid-co-butyl methacrylate) (p-DMAEMA-b-(DMAEMA-co-PAA-co-BMA)) were loaded with farnesol or apigenin for the controlled, pH-dependent release of the two agents to inhibit pathogenic bacteria-producing biofilms. The inventions are mainly directed against Streptococcus mutans, the oral cavity bacterium responsible for dental caries.
基于聚（甲基丙烯酸二甲氨基乙酯）-b-聚（甲基丙烯酸二甲氨基乙酯-共-丙基丙烯酸-共-甲基丙烯酸丁酯）（p-DMAEMA-b-(DMAEMA-共-PAA-共-BMA)）的纳米颗粒负载了法尼醇或芹菜素，用于这两种药物的可控、pH依赖释放，以抑制产生生物膜的致病细菌。这些发明主要针对变形链球菌，这种口腔细菌是导致龋齿的原因。
