哌仑西平对豚鼠离体壁细胞摄取氨基比林的影响。

Effect of pirenzepine on aminopyrine uptake by isolated guinea pig parietal cells.

作者信息

Tani N, Watanabe Y, Mutoh N, Karasawa H, Hara M, Miwa T

机构信息

Dept. of Internal Medicine, School of Medicine, Tokai University, Kanagawa Prefecture, Japan.

出版信息

Scand J Gastroenterol. 1989 Dec;24(10):1159-62. doi: 10.3109/00365528909090781.

DOI:10.3109/00365528909090781

PMID:2602899

Abstract

The inhibitory action of pirenzepine on acid secretion of isolated guinea pig parietal cells was investigated by the aminopyrine method. Pirenzepine markedly inhibited acid secretion of isolated parietal cells induced by carbachol in a dose-dependent manner but showed no inhibition on acid secretion stimulated by histamine. These results may suggest a direct action of pirenzepine on muscarinic receptors in parietal cells.

摘要

采用氨基比林法研究了哌仑西平对豚鼠离体壁细胞酸分泌的抑制作用。哌仑西平可显著抑制由卡巴胆碱诱导的离体壁细胞酸分泌，且呈剂量依赖性，但对组胺刺激的酸分泌无抑制作用。这些结果可能提示哌仑西平对壁细胞毒蕈碱受体有直接作用。