Prisco Vincenzo, Iannaccone Teresa, Volpe Umberto, Fabrazzo Michele
Department of Psychiatry, University of Naples SUN, Naples, Italy.
BMJ Case Rep. 2015 Jun 1;2015:bcr2014209148. doi: 10.1136/bcr-2014-209148.
Anecdotal evidence tends to suggest clozapine treatment as a cause of leucocytosis in schizophrenic patients, however, no conclusive evidence is available on this topic. We report the clinical cases of two schizophrenic men who were diagnosed with clozapine-related leucocytosis. The clozapine treatment was performed at a dose between 200 and 400 mg/day. When leucocytosis appeared, there was a loss of response to clozapine in both patients. Clozapine-induced leucocytosis in schizophrenic patients could be correlated to occurrence of psychotic symptomatology.
轶事证据倾向于表明氯氮平治疗是精神分裂症患者白细胞增多的一个原因，然而，关于这个主题尚无确凿证据。我们报告了两名被诊断为氯氮平相关性白细胞增多的男性精神分裂症患者的临床病例。氯氮平治疗剂量为每日200至400毫克。当出现白细胞增多时，两名患者对氯氮平均失去反应。精神分裂症患者中氯氮平诱发的白细胞增多可能与精神病性症状的发生有关。
