Lothschütz Christian, Wurm Thomas, Zeiler Anna, Freiherr V Falkenhausen Alexander, Rudolph Matthias, Rominger Frank, Hashmi A Stephen K
Organisch-Chemisches Institut, Universität Heidelberg, Im Neuenheimer Feld 270, 69120, Heidelberg, Germany), Fax: (+49) 06221-54-4205.
Chem Asian J. 2016 Feb 4;11(3):342-6. doi: 10.1002/asia.201500353. Epub 2015 Jul 3.
The scope and limitations of the isonitrile-based NHC template synthesis were investigated with a series of precursors containing a nucleophilic amine in combination with tethered electrophiles. In the case of alkynes and phosphonic esters as electrophiles no ring closure was observed and new functionalized NAC gold complexes were obtained. By the use of unsaturated esters and phosphonic esters as Michael acceptors in the amine precursors, ester-modified gold and palladium NHC complexes were accessible in high efficiency.
通过一系列含有亲核胺并与连接的亲电试剂相结合的前体，研究了异腈基NHC模板合成的范围和局限性。在炔烃和膦酸酯作为亲电试剂的情况下，未观察到环化反应，而是得到了新的功能化NAC金配合物。通过在胺前体中使用不饱和酯和膦酸酯作为迈克尔受体，可以高效地获得酯修饰的金和钯NHC配合物。
