异金属卡宾金（I）-铂（II）和金（I）-钯（II）配合物在癌细胞系中的抗增殖活性比较研究。

Comparative study of the antiproliferative activity of heterometallic carbene gold(i)-platinum(ii) and gold(i)-palladium(ii) complexes in cancer cell lines.

作者信息

Dietl Martin C, Maag Melina, Ber Sophia, Rominger Frank, Rudolph Matthias, Caligiuri Isabella, Andele Pacome K, Mkhalid Ibraheem A I, Rizzolio Flavio, Nogara Pablo A, Orian Laura, Scattolin Thomas, Hashmi A Stephen K

机构信息

Organisch-Chemisches Institut, Heidelberg University Im Neuenheimer Feld 270 69120 Heidelberg Germany

Pathology Unit, Centro di Riferimento Oncologico di Aviano (C.R.O.) IRCCS via Franco Gallini 2 33081 Aviano Italy.

出版信息

Chem Sci. 2024 Aug 29;15(37):15291-8. doi: 10.1039/d4sc04585h.

The stepwise, one-pot synthesis of heterobimetallic carbene gold(i) platinum(ii) complexes from readily available starting materials is presented. The protecting group free methodology is based on the graduated nucleophilicities of aliphatic and aromatic amines as linkers between both metal centers. This enables the selective, sequential installation of the metal fragments. In addition, the obtained complexes were tested as potential anticancer agents and directly compared to their gold(i) palladium(ii) counterparts.