Kramer Christopher M
Cardiovascular Imaging Center, University of Virginia Health System, Charlottesville, Virginia
J Nucl Med. 2015 Jun;56 Suppl 4(0 4):39S-45S. doi: 10.2967/jnumed.114.142729.
Cardiac MR imaging has made major inroads in the new millennium in the diagnosis and assessment of prognosis for patients with cardiomyopathies. Imaging of left and right ventricular structure and function and tissue characterization with late gadolinium enhancement (LGE) as well as T1 and T2 mapping enable accurate diagnosis of the underlying etiology. In the setting of coronary artery disease, either transmurality of LGE or contractile reserve in response to dobutamine can assess the likelihood of recovery of function after revascularization. The presence of scar reduces the likelihood of a response to medical therapy and to cardiac resynchronization therapy in heart failure. The presence and extent of LGE relate to overall cardiovascular outcome in cardiomyopathies. A major role for cardiac MR imaging in cardiomyopathies is to identify myocardial scar for diagnostic and prognostic purposes.
在新千年里,心脏磁共振成像在心肌病患者的诊断和预后评估方面取得了重大进展。通过钆延迟增强(LGE)以及T1和T2映射对左、右心室结构和功能进行成像以及组织特征分析,能够准确诊断潜在病因。在冠状动脉疾病的情况下,LGE的透壁性或对多巴酚丁胺的收缩储备可评估血运重建后功能恢复的可能性。瘢痕的存在降低了心力衰竭患者对药物治疗和心脏再同步治疗产生反应的可能性。LGE的存在和范围与心肌病的总体心血管结局相关。心脏磁共振成像在心肌病中的一个主要作用是为了诊断和预后目的识别心肌瘢痕。