Haji-Ghassemi Omid, Blackler Ryan J, Martin Young N, Evans Stephen V
Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, Canada V8P 3P6.
Human Health Therapeutics, National Research Council of Canada, 100 Sussex Drive, Ottawa, ON, Canada K1A 0R6.
Glycobiology. 2015 Sep;25(9):920-52. doi: 10.1093/glycob/cwv037. Epub 2015 Jun 1.
Carbohydrate antigens are valuable as components of vaccines for bacterial infectious agents and human immunodeficiency virus (HIV), and for generating immunotherapeutics against cancer. The crystal structures of anti-carbohydrate antibodies in complex with antigen reveal the key features of antigen recognition and provide information that can guide the design of vaccines, particularly synthetic ones. This review summarizes structural features of anti-carbohydrate antibodies to over 20 antigens, based on six categories of glyco-antigen: (i) the glycan shield of HIV glycoproteins; (ii) tumor epitopes; (iii) glycolipids and blood group A antigen; (iv) internal epitopes of bacterial lipopolysaccharides; (v) terminal epitopes on polysaccharides and oligosaccharides, including a group of antibodies to Kdo-containing Chlamydia epitopes; and (vi) linear homopolysaccharides.
碳水化合物抗原作为细菌感染因子和人类免疫缺陷病毒（HIV）疫苗的组成成分，以及用于生成抗癌免疫疗法，具有重要价值。与抗原结合的抗碳水化合物抗体的晶体结构揭示了抗原识别的关键特征，并提供了可指导疫苗设计（尤其是合成疫苗设计）的信息。本综述基于六类糖抗原，总结了针对20多种抗原的抗碳水化合物抗体的结构特征：（i）HIV糖蛋白的聚糖屏蔽；（ii）肿瘤表位；（iii）糖脂和A血型抗原；（iv）细菌脂多糖的内部表位；（v）多糖和寡糖上的末端表位，包括一组针对含Kdo的衣原体表位的抗体；以及（vi）线性同多糖。
