Rosario-Colon Jonothan, Eberle Karen, Xin Hong
LSU Health Sciences Center New Orleans, New Orleans, LA, USA.
iScience. 2025 Apr 16;28(5):112459. doi: 10.1016/j.isci.2025.112459. eCollection 2025 May 16.
species are a major cause of severe fungal infections, particularly in immunocompromised individuals and hospitalized patients. Among these, stands out as an emerging "superbug", responsible for life-threatening bloodstream infections with mortality rates up to 60%. This multidrug-resistant, hospital-acquired pathogen has been declared a serious global health threat, complicating effective treatment and increasing mortality risks. Our research has identified universal monoclonal antibodies (mAbs) targeting cell wall epitopes, which are highly homologous to those in other pathogenic species, including Passive transfer of mAbs-C3.1 (anti-β-1,2-mannotriose) and 9F2 (anti-phosphoglycerate kinase 1)-significantly extended survival and improved fungal clearance in a complement C5-deficient A/J murine model. Additionally, C3.1 and 9F2 mAbs show direct fungicidal effects against isolates, presenting a promising therapeutic option against this critical threat.
某些真菌物种是严重真菌感染的主要原因，尤其是在免疫功能低下的个体和住院患者中。其中，[具体真菌名称]作为一种新兴的“超级细菌”脱颖而出，它会引发危及生命的血流感染，死亡率高达60%。这种耐多药的医院获得性病原体已被宣布为严重的全球健康威胁，使有效治疗变得复杂并增加了死亡风险。我们的研究已经鉴定出针对[具体真菌名称]细胞壁表位的通用单克隆抗体（mAb），这些表位与其他致病性[具体真菌名称]物种中的表位高度同源，包括[相关真菌名称]。在补体C5缺陷的A/J小鼠模型中，单克隆抗体C3.1（抗β-1,2-甘露三糖）和9F2（抗磷酸甘油酸激酶1）的被动转移显著延长了生存期并改善了真菌清除率。此外，C3.1和9F2单克隆抗体对[具体真菌名称]分离株显示出直接的杀菌作用，为应对这一关键威胁提供了一种有前景的治疗选择。
