使用钌催化的C-H官能化反应实现韦纳布酰胺的藤原-森谷反应
Fujiwara-Moritani Reaction of Weinreb Amides using a Ruthenium-Catalyzed C-H Functionalization Reaction.
作者信息
Das Riki, Kapur Manmohan
机构信息
Department of Chemistry, Indian Institute of Science Education and Research Bhopal, Academic Building II, Indore Bypass Road, Bhauri, Bhopal, 462066, MP, India.
出版信息
Chem Asian J. 2015 Jul;10(7):1505-12. doi: 10.1002/asia.201500343. Epub 2015 May 29.
The ruthenium-catalyzed Fujiwara-Moritani reaction (oxidative-Heck reaction) of Weinreb amides is reported herein. The reaction affords exclusively ortho-C-H olefination products, has excellent substrate scope and tolerates halogen functionalities, which increase the synthetic utility of the method. A variety of activated olefins as well as styrenes can be employed as coupling partners.
本文报道了钌催化的Weinreb酰胺的藤原-森谷反应（氧化-Heck反应）。该反应专一性地生成邻位C-H烯基化产物，具有出色的底物范围，并且能够耐受卤素官能团，这增加了该方法的合成实用性。多种活性烯烃以及苯乙烯都可用作偶联伙伴。
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