通过色氨酸和烯烃之间的藤原-森田反应构建订书肽的后期阶段。
Late-stage construction of stapled peptides through Fujiwara-Moritani reaction between tryptophan and olefins.
机构信息
Key Laboratory of Bioorganic Synthesis of Zhejiang Province, College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310014, China.
出版信息
Chem Commun (Camb). 2021 Nov 4;57(88):11661-11664. doi: 10.1039/d1cc04202e.
PMID:34671802
Abstract
Herein, the first example of a palladium-catalyzed Fujiwara-Moritani reaction for olefination of tryptophan (Trp) residues, free from directing groups, was presented. The developed reaction proceeds efficiently for peptide modification, ligation and peptide stapling.
摘要
本文首次报道了钯催化的没有导向基团的色氨酸（Trp）残基的富吉wara-Moritani 反应用于烯烃化。所开发的反应可有效地用于肽修饰、连接和肽键合成。
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