Bröker Michael, Emonet Stéphane, Fazio Cecilia, Jacobsson Susanne, Koliou Maria, Kuusi Markku, Pace David, Paragi Metka, Pysik Alexander, Simões Maria João, Skoczynska Anna, Stefanelli Paola, Toropainen Maija, Taha Muhamed-Kheir, Tzanakaki Georgina
a Novartis Vaccines and Diagnostics GmbH ; Marburg , Germany.
Hum Vaccin Immunother. 2015;11(9):2281-6. doi: 10.1080/21645515.2015.1051276.
Neisseria meningitidis or meningococcus is divided into 12 distinct serogroups of which A, B, C, W, X, and Y are medically most important and cause health problems in different parts of the world. The epidemiology of N. meningitidis is unpredictable over time and across geographic regions. Globally, serogroup A has been prevalent in the African "meningitis belt" whereas serogroup B and C have predominated in Europe. In a paper published earlier in this journal (1) , an increase in serogroup Y invasive meningococcal disease (IMD) in some European countries was reported based on the epidemiological data for 2010, 2011 and 2012. Here, we report additional data from 30 European countries indicating that high or increased serogroup Y disease levels have continued in 2013 in certain regions of Europe. In the Western and Central Europe, there were no major changes in the proportion of serogroup Y IMD cases in 2013 compared to 2012. In the Scandinavian countries, proportion of serogroup Y disease remained high, ranging from 26% to 51% in 2013. This was in contrast to Baltic, Eastern and most Southern European countries, where the proportion of serogroup Y IMD was low similarly to previous years. For the last 2 decades, the mean age of patients affected by serogroup Y was 41 y for 7 countries from which data was available and 50% of cases were in patients aged 45 to 88 y. The age distribution of serogroup Y was bimodal and did not change significantly despite the increase of the total number and the proportion of serogroup Y IMD in some European regions.
脑膜炎奈瑟菌或脑膜炎球菌可分为12个不同的血清群，其中A、B、C、W、X和Y在医学上最为重要，且在世界不同地区引发健康问题。脑膜炎奈瑟菌的流行病学情况随时间和地理区域的变化而不可预测。在全球范围内，A血清群在非洲“脑膜炎带”流行，而B和C血清群在欧洲占主导地位。在本期刊早些时候发表的一篇论文中（1），根据2010年、2011年和2012年的流行病学数据，报告了一些欧洲国家Y血清群侵袭性脑膜炎球菌病（IMD）有所增加。在此，我们报告来自30个欧洲国家的更多数据，表明2013年欧洲某些地区Y血清群疾病水平持续居高或有所上升。在西欧和中欧，2013年Y血清群IMD病例的比例与2012年相比没有重大变化。在斯堪的纳维亚国家，Y血清群疾病的比例仍然很高，2013年在26%至51%之间。这与波罗的海、东欧和大多数南欧国家形成对比，在这些国家，Y血清群IMD的比例与前几年一样低。在过去20年中，有数据可用的7个国家中，受Y血清群影响患者的平均年龄为41岁，50%的病例发生在45至88岁的患者中。Y血清群的年龄分布呈双峰型，尽管在一些欧洲地区Y血清群IMD的总数和比例有所增加，但分布并未发生显著变化。
