用于检测人体石棉暴露反应生物标志物的生物分析技术。
Bioanalytical techniques for detecting biomarkers of response to human asbestos exposure.
作者信息
Mesaros Clementina, Worth Andrew J, Snyder Nathaniel W, Christofidou-Solomidou Melpo, Vachani Anil, Albelda Steven M, Blair Ian A
机构信息
1Penn SRP Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-6160, USA.
2Center of Excellence in Environmental Toxicology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-6160, USA.
出版信息
Bioanalysis. 2015;7(9):1157-73. doi: 10.4155/bio.15.53.
Asbestos exposure is known to cause lung cancer and mesothelioma and its health and economic impacts have been well documented. The exceptionally long latency periods of most asbestos-related diseases have hampered preventative and precautionary steps thus far. We aimed to summarize the state of knowledge on biomarkers of response to asbestos exposure. Asbestos is not present in human biological fluids; rather it is inhaled and trapped in lung tissue. Biomarkers of response, which reflect a change in biologic function in response to asbestos exposure, are analyzed. Several classes of molecules have been studied and evaluated for their potential utility as biomarkers of asbestos exposure. These studies range from small molecule oxidative stress biomarkers to proteins involved in immune responses.
已知接触石棉会导致肺癌和间皮瘤，其对健康和经济的影响已有充分记录。迄今为止，大多数与石棉相关疾病的潜伏期极长，这阻碍了预防和防范措施的实施。我们旨在总结关于石棉接触反应生物标志物的知识现状。石棉不存在于人体生物体液中；相反，它被吸入并滞留在肺组织中。对反映因接触石棉而导致生物功能变化的反应生物标志物进行分析。已对几类分子进行了研究和评估，以确定它们作为石棉接触生物标志物的潜在效用。这些研究范围从小分子氧化应激生物标志物到参与免疫反应的蛋白质。
Zotero 插件