Placidi D, Porru S, Alessio L
Cattedra di Medicina del Lavoro, Università degli Studi di Brescia.
Med Lav. 1999 Sep-Oct;90(5):671-80.
The occurrence of malignant pleural mesothelioma (MT) is a sentinel event in occupational and environmental medicine. The association of pleural MT and asbestos exposure is well documented and it is well known that no threshold can be demonstrated below which there is no risk of developing MT. During the period 1994-1998, 3 patients were referred from the Pneumology Division to the Occupational Medicine Department of the Spedali Civili in Brescia. They had MT and they had a peculiar asbestos exposure. A thorough occupational and environmental history was taken by means of a standardized questionnaire. The first patient was environmentally exposed to crocidolite when she lived near an asbestos mine in Australia. The second was a teacher and the third was a goldsmith and both were occupationally exposed to asbestos. The case descriptions revealed the importance of a standardized evaluation of occupational and environmental exposure to asbestos. In this way otherwise ignored asbestos exposures can be identified therefore avoiding an underestimation of MT attributable to asbestos. The role of the occupational physician, both in hospital referrals and while taking standardized histories, is also stressed along with the importance of this contribution on the one hand to the epidemiological recording of sentinel events and on the other to the etiological definition of the cases, which was in fact our principal aim.
恶性胸膜间皮瘤(MT)的发生是职业与环境医学中的一个标志性事件。胸膜MT与石棉暴露之间的关联已有充分记录,并且众所周知,不存在一个能证明低于该阈值就不会发生MT风险的界限。在1994年至1998年期间,有3名患者从肺病科转诊至布雷西亚市公民医院的职业医学科。他们患有MT且有特殊的石棉暴露情况。通过标准化问卷对其职业和环境病史进行了全面询问。第一名患者在澳大利亚居住于石棉矿附近时受到环境中蓝石棉的暴露。第二名是一名教师,第三名是一名金匠,两人均有职业性石棉暴露。病例描述揭示了对石棉职业和环境暴露进行标准化评估的重要性。通过这种方式,可以识别出原本被忽视的石棉暴露,从而避免低估由石棉导致的MT。文中还强调了职业医生在医院转诊以及获取标准化病史过程中的作用,以及这种贡献一方面对标志性事件的流行病学记录、另一方面对病例病因学定义的重要性,而这实际上是我们的主要目的。