癌症研究中的转化代谢组学。
Translational metabolomics in cancer research.
作者信息
Snyder Nathaniel W, Mesaros Clementina, Blair Ian A
机构信息
Penn SRP Center & Excellence in Environmental Toxicology, Department of Systems Pharmacology & Translational Therapeutics, University of Pennsylvania, PA 19104, USA.
AJ Drexel Autism Institute, Drexel University, PA 19104, USA.
出版信息
Biomark Med. 2015;9(9):821-34. doi: 10.2217/bmm.15.52. Epub 2015 Sep 1.
Abstract
Over the last decade there has been a bottleneck in the introduction of new validated cancer metabolic biomarkers into clinical practice. Unfortunately, there are no biomarkers with adequate sensitivity for the early detection of cancer, and there remain a reliance on cancer antigens for monitoring treatment. The need for new diagnostics has led to the exploration of untargeted metabolomics for discovery of early biomarkers of specific cancers and targeted metabolomics to elucidate mechanistic aspects of tumor progression. The successful translation of such strategies to the treatment of cancer would allow earlier intervention to improve survival. We have reviewed the methodology that is being used to achieve these goals together with recent advances in implementing translational metabolomics in cancer.
摘要
在过去十年中，将新的经过验证的癌症代谢生物标志物引入临床实践一直存在瓶颈。不幸的是，目前尚无对癌症早期检测具有足够敏感性的生物标志物，且仍依赖癌症抗原进行治疗监测。对新型诊断方法的需求促使人们探索非靶向代谢组学以发现特定癌症的早期生物标志物，并探索靶向代谢组学以阐明肿瘤进展的机制。将这些策略成功转化用于癌症治疗将使早期干预得以实现，从而提高生存率。我们综述了为实现这些目标所采用的方法以及在癌症中实施转化代谢组学的最新进展。
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