Monteiro Afif F, Batista João M, Machado Michelle A, Severino Richele P, Blanch Ewan W, Bolzani Vanderlan S, Vieira Paulo C, Severino Vanessa G P
†Unidade Acadêmica Especial de Física e Química, Universidade Federal de Goiás, Avenida Dr. Lamartine Pinto de Avelar, 1120, 75704-020, Catalão, GO, Brazil.
‡Departamento de Química Orgânica, Universidade Estadual Paulista "Júlio de Mesquita Filho", Rua Prof. Francisco Degni, 55, 14800-060, Araraquara, SP, Brazil.
J Nat Prod. 2015 Jun 26;78(6):1451-5. doi: 10.1021/acs.jnatprod.5b00166. Epub 2015 Jun 3.
Chemical investigations of the ethanolic extracts from the flowers and leaves of Hymenaea stigonocarpa Mart. ex Hayne afforded one new ent-halimane diterpenoid, 18-hydroxy-ent-halima-1(10),13-(E)-dien-15-oic acid (1), together with five known compounds (2-6). The structural elucidation was performed by means of NMR (COSY, HSQC, HMBC, and NOESY) and MS analyses. Complete (1)H and (13)C NMR data assignments are also reported for labd-13-en-8β-ol-15-oic (2) and labd-7,13-dien-15-oic (3) acids. The absolute configurations of 1 and 2 were established by comparison of experimental and calculated Raman optical activity spectra.
对孪叶豆（Hymenaea stigonocarpa Mart. ex Hayne）花和叶的乙醇提取物进行化学研究，得到了一种新的对映-海松烷二萜，18-羟基-对映-海松-1(10),13-(E)-二烯-15-酸（1），以及五种已知化合物（2 - 6）。通过核磁共振（COSY、HSQC、HMBC和NOESY）和质谱分析进行结构解析。还报道了唇形-13-烯-8β-醇-15-酸（2）和唇形-7,13-二烯-15-酸（3）完整的¹H和¹³C核磁共振数据归属。通过比较实验和计算的拉曼光学活性光谱确定了1和2的绝对构型。
