Chih C P, Rosenthal M, Sick T J
Department of Neurology, University of Miami, School of Medicine, Florida 33101.
Am J Physiol. 1989 Dec;257(6 Pt 2):R1562-4. doi: 10.1152/ajpregu.1989.257.6.R1562.
The turtle brain maintains ATP levels, ion homeostasis, and some neural function during prolonged anoxia despite significant decreases in the rate of ATP production. To test the hypothesis that reduced ATP production during anoxia was compensated partly by conserving energy through reduced ion leakage, the rate of K+ leakage was measured in normoxic and anoxic turtle brains in which Na(+)-K(+)-adenosinetriphosphatase was inhibited with ouabain. Rates of K+ leakage were significantly lower in brains subjected to 2 h of anoxia than in normoxic brains. These data support the suggestion that reduced ion leakage is an important mechanism for energy conservation during anoxia.
尽管在长时间缺氧期间三磷酸腺苷（ATP）生成速率显著下降，但乌龟大脑仍能维持ATP水平、离子稳态及某些神经功能。为验证缺氧期间ATP生成减少部分是通过减少离子泄漏来保存能量这一假说，在常氧和缺氧的乌龟大脑中测量钾离子（K⁺）泄漏速率，其中用哇巴因抑制钠钾三磷酸腺苷酶（Na⁺-K⁺-ATP酶）。经历2小时缺氧的大脑中K⁺泄漏速率显著低于常氧大脑。这些数据支持了以下观点：减少离子泄漏是缺氧期间保存能量的重要机制。
