血管紧张素转换酶插入/缺失基因多态性与心房颤动风险的相关性：23项病例对照研究的荟萃分析。
Angiotensin-converting enzyme insertion/deletion gene polymorphisms associated with risk of atrial fibrillation: A meta-analysis of 23 case-control studies.
作者信息
Ma Runwei, Li Xiang, Su Guoning, Hong Yunfei, Wu Xingjian, Wang Jiyang, Zhao Ziliang, Song Yi, Ma Shaohong
机构信息
Department of Cardiovascular Surgery, the No. 4 Affiliated Hospital of Kunming Medical University, China
Department of Cardiovascular Surgery, the No. 4 Affiliated Hospital of Kunming Medical University, China.
出版信息
J Renin Angiotensin Aldosterone Syst. 2015 Dec;16(4):793-800. doi: 10.1177/1470320315587179. Epub 2015 Jun 3.
AIMS
The renin-angiotensin-aldosterone system is important to the development of atrial fibrillation (AF). A lot of research has focused on the relationship between angiotensin-converting enzyme (ACE) insertion (I) /deletion (D) gene polymorphisms and AF, with inconsistent results. A meta-analysis was carried out to find the correlation between ACE I/D gene polymorphisms and AF.
METHODS
Data were extracted from articles published before September 2013 on ACE I/D polymorphisms and AF in Embase, PubMed, WanFangData, and China National Knowledge Infrastructure.
RESULTS
The recessive model found that ACE I/D gene polymorphisms were related to AF (odds ratio (OR) = 1.61, 95% confidence interval (CI) = 1.16-1.72). Subgroup analysis showed a significant association in the recessive model for Asian (OR = 1.40, 95% CI = 1.19-1.80) and Caucasian (OR = 1.42, 95% CI = 1.01-1.99) populations.
CONCLUSIONS
ACE I/D gene polymorphisms and AF are significantly related to ethnicity. Individuals with the ACE D/D genotype appear to be at higher risk of AF.
目的
肾素-血管紧张素-醛固酮系统对心房颤动（房颤）的发生发展至关重要。许多研究聚焦于血管紧张素转换酶（ACE）插入（I）/缺失（D）基因多态性与房颤之间的关系，结果并不一致。开展一项荟萃分析以探寻ACE I/D基因多态性与房颤之间的相关性。
方法
从2013年9月之前发表在Embase、PubMed、万方数据和中国知网中关于ACE I/D多态性与房颤的文章中提取数据。
结果
隐性模型发现ACE I/D基因多态性与房颤相关（比值比（OR）=1.61，95%置信区间（CI）=1.16 - 1.72）。亚组分析显示，在亚洲人群（OR = 1.40，95% CI = 1.19 - 1.80）和白种人群（OR = 1.42，95% CI = 1.01 - 1.99）的隐性模型中存在显著关联。
结论
ACE I/D基因多态性与房颤显著相关，且与种族有关。携带ACE D/D基因型的个体似乎患房颤的风险更高。
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