血管紧张素转换酶I/D多态性与肺炎风险相关：一项荟萃分析。
Angiotensin-converting enzyme I/D polymorphism is associated with pneumonia risk: a meta-analysis.
作者信息
Nie Wei, Zang Yuansheng, Chen Jiquan, Liu Tao, Xiao Lin, Xiu Qingyu
机构信息
Department of Respiratory Disease, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, China.
Department of Respiratory Disease, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, China
出版信息
J Renin Angiotensin Aldosterone Syst. 2014 Dec;15(4):585-92. doi: 10.1177/1470320313507622. Epub 2014 Feb 4.
BACKGROUND
Previous studies examined the association between angiotensin-converting enzyme (ACE) I/D polymorphism and pneumonia, but their results were inconsistent. Thus, a meta-analysis was performed to clarify the effect of ACE I/D polymorphism on pneumonia risk and pneumonia-related mortality.
METHODS
The PubMed, Embase, and Chinese National Knowledge Infrastructure (CNKI) databases were searched for relevant studies published up to 27 April 2013. Data were extracted and pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated.
RESULTS
Pooled analysis of 12 case-control studies (1431 cases and 3600 controls) showed that there was a significant association between ACE I/D polymorphism and pneumonia risk in a recessive genetic model (OR = 1.53, 95% CI 1.30-1.80, p < 0.00001). No significant association between ACE I/D polymorphism and mortality was observed (OR = 2.68, 95% CI 0.80-8.90, p = 0.11).
CONCLUSIONS
Our meta-analysis confirmed that ACE I/D polymorphism was associated with pneumonia risk. However, ACE I/D polymorphism was not associated with pneumonia mortality.
背景
既往研究探讨了血管紧张素转换酶（ACE）I/D多态性与肺炎之间的关联，但其结果并不一致。因此，进行了一项荟萃分析以阐明ACE I/D多态性对肺炎风险及肺炎相关死亡率的影响。
方法
检索了PubMed、Embase和中国国家知识基础设施（CNKI）数据库中截至2013年4月27日发表的相关研究。提取数据并计算合并比值比（OR）及95%置信区间（CI）。
结果
对12项病例对照研究（1431例病例和3600例对照）的合并分析显示，在隐性遗传模型中，ACE I/D多态性与肺炎风险之间存在显著关联（OR = 1.53，95%CI 1.30 - 1.80，p < 0.00001）。未观察到ACE I/D多态性与死亡率之间存在显著关联（OR = 2.68，95%CI 0.80 - 8.90，p = 0.11）。
结论
我们的荟萃分析证实，ACE I/D多态性与肺炎风险相关。然而，ACE I/D多态性与肺炎死亡率无关。
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