Simmons Daimon P, Savage William J
Department of Pathology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA.
Department of Pathology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA.
Hematol Oncol Clin North Am. 2015 Jun;29(3):429-43. doi: 10.1016/j.hoc.2015.01.003. Epub 2015 Mar 10.
ABO incompatibility of red blood cells leads to brisk complement-mediated lysis, particularly in the setting of red cell transfusion. The ABO blood group is the most clinically significant blood group because of preformed immunoglobulin M (IgM) and IgG antibodies to ABO blood group antigens (isohemagglutinins) in everyone except group AB individuals. In addition to transfusion, ABO incompatibility can cause hemolysis in hematopoietic and solid organ transplantation, hemolytic disease of the newborn, and intravenous immunoglobulin infusion. It is important to prevent ABO incompatibility when possible and to anticipate complications when ABO incompatibility is unavoidable.
红细胞的ABO血型不相容会导致补体介导的快速溶血，尤其是在红细胞输血的情况下。ABO血型是临床上最重要的血型，因为除AB血型个体外，每个人体内都预先存在针对ABO血型抗原的免疫球蛋白M（IgM）和IgG抗体（同种血凝素）。除输血外，ABO血型不相容还可导致造血和实体器官移植中的溶血、新生儿溶血病以及静脉注射免疫球蛋白。尽可能预防ABO血型不相容并在不可避免时预测并发症很重要。
