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[乳腺癌的预防性腋窝放疗]

[Prophylactic axillary radiotherapy for breast cancer].

作者信息

Rivera S, Louvel G, Rivin Del Campo E, Boros A, Oueslati H, Deutsch É

机构信息

Département d'oncologie radiothérapie, institut Gustave-Roussy, 114, rue Édouard-Vaillant, 94800 Villejuif, France.

Département d'oncologie radiothérapie, institut Gustave-Roussy, 114, rue Édouard-Vaillant, 94800 Villejuif, France.

出版信息

Cancer Radiother. 2015 Jun;19(4):253-60. doi: 10.1016/j.canrad.2015.05.001. Epub 2015 Jun 1.

DOI:10.1016/j.canrad.2015.05.001
PMID:26044178
Abstract

Adjuvant radiotherapy, after breast conserving surgery or mastectomy for breast cancer, improves overall survival while decreasing the risk of recurrence. However, prophylactic postoperative radiotherapy of locoregional lymph nodes for breast cancer, particularly of the axillary region, is still controversial since the benefits and the risks due to axillary irradiation have not been well defined. To begin with, when performing conformal radiotherapy, volume definition is crucial for the analysis of the risk-benefit balance of any radiation treatment. Definition and contouring of the axillary lymph node region is discussed in this work, as per the recommendations of the European Society for Radiotherapy and Oncology (ESTRO). Axillary recurrences are rare, and the recent trend leads toward less aggressive surgery with regard to the axilla. In this literature review we present the data that lead us to avoid adjuvant axillary radiotherapy in pN0, pN0i+ and pN1mi patients even without axillary clearance and to perform it in some other situations. Finally, we propose an update about the potential toxicity of adjuvant axillary irradiation, which is essential for therapeutic decision-making based on current evidence, and to guide us in the evolution of our techniques and indications of axillary radiotherapy.

摘要

辅助放疗,在乳腺癌保乳手术或乳房切除术后,可提高总生存率,同时降低复发风险。然而,乳腺癌局部区域淋巴结的预防性术后放疗,尤其是腋窝区域,仍存在争议,因为腋窝放疗的益处和风险尚未明确界定。首先,在进行适形放疗时,体积定义对于分析任何放射治疗的风险效益平衡至关重要。根据欧洲放射肿瘤学会(ESTRO)的建议,本文讨论了腋窝淋巴结区域的定义和轮廓勾画。腋窝复发很少见,最近的趋势是在腋窝方面采取不太激进的手术方式。在这篇文献综述中,我们展示了一些数据,这些数据使我们即使在未进行腋窝清扫的情况下,也避免对pN0、pN0i+和pN1mi患者进行辅助腋窝放疗,而在其他一些情况下进行放疗。最后,我们提出了关于辅助腋窝放疗潜在毒性的最新情况,这对于基于当前证据的治疗决策至关重要,并指导我们在腋窝放疗技术和适应证的发展中做出决策。

相似文献

1
[Prophylactic axillary radiotherapy for breast cancer].[乳腺癌的预防性腋窝放疗]
Cancer Radiother. 2015 Jun;19(4):253-60. doi: 10.1016/j.canrad.2015.05.001. Epub 2015 Jun 1.
2
[Diffusion prophylactic axillary irradiation in breast cancer - Literature review].[乳腺癌的扩散预防性腋窝照射——文献综述]
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Cancer Radiother. 2015 Jun;19(4):284-7. doi: 10.1016/j.canrad.2015.03.008. Epub 2015 May 23.
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[Axillary lymph node irradiation in breast cancer: state of the art].
Bull Cancer. 2012 Apr 1;99(4):471-7. doi: 10.1684/bdc.2012.1548.
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[Management of the axilla in breast cancer: evidences and unresolved issues].[乳腺癌腋窝的管理:证据与未解决的问题]
Orv Hetil. 2001 Sep 9;142(36):1941-50.
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Survival benefit of post-mastectomy radiotherapy in breast carcinoma patients with T1-2 tumor and 1-3 axillary lymph node(s) metastasis.保乳术后放疗对 T1-2 期肿瘤和 1-3 个腋窝淋巴结转移的乳腺癌患者的生存获益。
Jpn J Clin Oncol. 2012 Jul;42(7):601-8. doi: 10.1093/jjco/hys052. Epub 2012 Apr 17.
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Radiotherapy of breast cancer.乳腺癌放射治疗。
Cancer Radiother. 2022 Feb-Apr;26(1-2):221-230. doi: 10.1016/j.canrad.2021.11.013. Epub 2021 Dec 23.
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Radiation field design and regional control in sentinel lymph node-positive breast cancer patients with omission of axillary dissection.哨兵淋巴结阳性乳腺癌患者省略腋窝清扫术后的放射野设计和区域控制。
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[Evidence-based radiotherapy in the treatment of operable breast cancer: results in the 1990-ies].[基于证据的放射治疗在可手术乳腺癌治疗中的应用:20世纪90年代的结果]
Orv Hetil. 2000 Jul 9;141(28):1551-5.

引用本文的文献

1
Should the management of radiation therapy for breast cancer be standardized? Results of a survey on current French practices in breast radiotherapy.乳腺癌放射治疗的管理应该标准化吗?关于法国目前乳腺癌放射治疗实践的一项调查结果。
Rep Pract Oncol Radiother. 2021 Sep 30;26(5):814-826. doi: 10.5603/RPOR.a2021.0102. eCollection 2021.
2
Management of the Axilla in the Era of Breast Cancer Heterogeneity.乳腺癌异质性时代的腋窝管理
Front Oncol. 2018 Apr 4;8:84. doi: 10.3389/fonc.2018.00084. eCollection 2018.