Rivera S, Louvel G, Rivin Del Campo E, Boros A, Oueslati H, Deutsch É
Département d'oncologie radiothérapie, institut Gustave-Roussy, 114, rue Édouard-Vaillant, 94800 Villejuif, France.
Département d'oncologie radiothérapie, institut Gustave-Roussy, 114, rue Édouard-Vaillant, 94800 Villejuif, France.
Cancer Radiother. 2015 Jun;19(4):253-60. doi: 10.1016/j.canrad.2015.05.001. Epub 2015 Jun 1.
Adjuvant radiotherapy, after breast conserving surgery or mastectomy for breast cancer, improves overall survival while decreasing the risk of recurrence. However, prophylactic postoperative radiotherapy of locoregional lymph nodes for breast cancer, particularly of the axillary region, is still controversial since the benefits and the risks due to axillary irradiation have not been well defined. To begin with, when performing conformal radiotherapy, volume definition is crucial for the analysis of the risk-benefit balance of any radiation treatment. Definition and contouring of the axillary lymph node region is discussed in this work, as per the recommendations of the European Society for Radiotherapy and Oncology (ESTRO). Axillary recurrences are rare, and the recent trend leads toward less aggressive surgery with regard to the axilla. In this literature review we present the data that lead us to avoid adjuvant axillary radiotherapy in pN0, pN0i+ and pN1mi patients even without axillary clearance and to perform it in some other situations. Finally, we propose an update about the potential toxicity of adjuvant axillary irradiation, which is essential for therapeutic decision-making based on current evidence, and to guide us in the evolution of our techniques and indications of axillary radiotherapy.
辅助放疗,在乳腺癌保乳手术或乳房切除术后,可提高总生存率,同时降低复发风险。然而,乳腺癌局部区域淋巴结的预防性术后放疗,尤其是腋窝区域,仍存在争议,因为腋窝放疗的益处和风险尚未明确界定。首先,在进行适形放疗时,体积定义对于分析任何放射治疗的风险效益平衡至关重要。根据欧洲放射肿瘤学会(ESTRO)的建议,本文讨论了腋窝淋巴结区域的定义和轮廓勾画。腋窝复发很少见,最近的趋势是在腋窝方面采取不太激进的手术方式。在这篇文献综述中,我们展示了一些数据,这些数据使我们即使在未进行腋窝清扫的情况下,也避免对pN0、pN0i+和pN1mi患者进行辅助腋窝放疗,而在其他一些情况下进行放疗。最后,我们提出了关于辅助腋窝放疗潜在毒性的最新情况,这对于基于当前证据的治疗决策至关重要,并指导我们在腋窝放疗技术和适应证的发展中做出决策。