乳腺癌异质性时代的腋窝管理
Management of the Axilla in the Era of Breast Cancer Heterogeneity.
作者信息
de Meric de Bellefon Maïlys, Lemanski Claire, Ducteil Angélique, Fenoglietto Pascal, Azria David, Bourgier Celine
机构信息
Institut Régional du Cancer de Montpellier (ICM), Montpellier, France.
Institut de Recherche en Cancérologie de Montpellier (IRCM), INSERM U1194, Montpellier, France.
出版信息
Front Oncol. 2018 Apr 4;8:84. doi: 10.3389/fonc.2018.00084. eCollection 2018.
Abstract
Systemic cancer therapies take into account breast cancer (BC) heterogeneity by targeting pathways specifically involved in some BC subtypes. On the other hand, BC intrinsic radiosensitivity is poorly understood and studied. Hence, radiotherapy personalization in BC is still "work in progress". In this review, we will summarize the existing data on the management of axillary lymph nodes in BC, the impact of BC radiotherapy on axillary management, the indications for axillary radiotherapy, and biomarkers to predict patients' outcome (tumor control and late toxicities) after axillary irradiation.
摘要
全身性癌症治疗通过靶向某些乳腺癌（BC）亚型特有的信号通路来考虑乳腺癌的异质性。另一方面，BC的内在放射敏感性却鲜为人知且研究较少。因此，BC放疗的个性化仍在“进行中”。在本综述中，我们将总结关于BC腋窝淋巴结管理的现有数据、BC放疗对腋窝管理的影响、腋窝放疗的适应症以及预测腋窝放疗后患者结局（肿瘤控制和晚期毒性）的生物标志物。
相似文献
1
Management of the Axilla in the Era of Breast Cancer Heterogeneity.乳腺癌异质性时代的腋窝管理
Front Oncol. 2018 Apr 4;8:84. doi: 10.3389/fonc.2018.00084. eCollection 2018.
2
[Management of the axilla in breast cancer: evidences and unresolved issues].[乳腺癌腋窝的管理：证据与未解决的问题]
Orv Hetil. 2001 Sep 9;142(36):1941-50.
3
Adjuvant radiotherapy in the management of axillary node negative invasive breast cancer: a qualitative systematic review.腋窝淋巴结阴性浸润性乳腺癌辅助放疗的管理：定性系统评价。
Crit Rev Oncol Hematol. 2013 Apr;86(1):33-41. doi: 10.1016/j.critrevonc.2012.09.010. Epub 2012 Oct 22.
4
Regional nodal recurrence in the management of breast cancer patients with one to three positive axillary lymph nodes. Outcome of patients following tangential irradiation without a separate nodal field.一至三个腋窝淋巴结阳性乳腺癌患者区域淋巴结复发情况。未设独立淋巴结照射野的切线照射患者的结局。
Strahlenther Onkol. 2004 Oct;180(10):623-8. doi: 10.1007/s00066-004-1241-2.
5
Management of the axilla in patients with breast cancer and positive sentinel lymph node biopsy: An evidence-based update in a European breast center.乳腺癌患者和前哨淋巴结活检阳性患者腋窝的处理：欧洲乳腺中心的循证更新。
Eur J Surg Oncol. 2020 Jan;46(1):15-23. doi: 10.1016/j.ejso.2019.08.013. Epub 2019 Aug 13.
6
How could breast cancer molecular features contribute to locoregional treatment decision making?乳腺癌分子特征如何有助于局部区域治疗决策？
Crit Rev Oncol Hematol. 2017 Feb;110:43-48. doi: 10.1016/j.critrevonc.2016.12.006. Epub 2016 Dec 8.
7
[Dissection or irradiation of the axilla in postmenopausal patients with breast cancer? Long-term results and long-term effects in 655 patients].
Strahlenther Onkol. 2002 Sep;178(9):510-6. doi: 10.1007/s00066-002-1035-3.
8
Axillary management still needed for patients with sentinel node micrometastases.前哨淋巴结微转移患者仍需腋窝处理。
Cancer Manag Res. 2019 Mar 8;11:2097-2100. doi: 10.2147/CMAR.S192573. eCollection 2019.
9
[Prophylactic axillary radiotherapy for breast cancer].[乳腺癌的预防性腋窝放疗]
Cancer Radiother. 2015 Jun;19(4):253-60. doi: 10.1016/j.canrad.2015.05.001. Epub 2015 Jun 1.
10
Regional nodal management and patterns of failure following conservative surgery and radiation therapy for stage I and II breast cancer.I期和II期乳腺癌保乳手术及放疗后的区域淋巴结管理与复发模式
Int J Radiat Oncol Biol Phys. 1993 Jul 15;26(4):593-9. doi: 10.1016/0360-3016(93)90274-y.
引用本文的文献
1
Predictive and Prognostic Values of Glycoprotein 96, Androgen Receptors, and Extranodal Extension in Sentinel Lymph Node-Positive Breast Cancer: An Immunohistochemical Retrospective Study.糖蛋白96、雄激素受体及前哨淋巴结阳性乳腺癌结外侵犯的预测和预后价值：一项免疫组织化学回顾性研究
J Clin Med. 2024 Dec 16;13(24):7665. doi: 10.3390/jcm13247665.
2
Assessment of the axilla in women with early-stage breast cancer undergoing primary surgery: a review.早期乳腺癌行原发性手术的女性腋窝评估：综述。
World J Surg Oncol. 2024 May 9;22(1):127. doi: 10.1186/s12957-024-03394-6.
3
Efficacy of sentinel lymph-node biopsy after neoadjuvant chemotherapy in clinically axilla node-negative patients.新辅助化疗后前哨淋巴结活检对临床腋窝淋巴结阴性患者的疗效。
Surg Today. 2024 Sep;54(9):1022-1030. doi: 10.1007/s00595-024-02837-7. Epub 2024 Apr 16.
4
Evaluation of different imaging modalities for axillary lymph node staging in breast cancer patients to provide a personalized and optimized therapy algorithm.评估不同的影像学方法在乳腺癌患者腋窝淋巴结分期中的应用，以提供个体化和优化的治疗方案。
J Cancer Res Clin Oncol. 2023 Jul;149(7):3457-3467. doi: 10.1007/s00432-022-04221-9. Epub 2022 Aug 10.
5
Non-invasive prediction of lymph node status for patients with early-stage invasive breast cancer based on a morphological feature from ultrasound images.基于超声图像形态学特征对早期浸润性乳腺癌患者淋巴结状态的无创预测
Quant Imaging Med Surg. 2021 Aug;11(8):3399-3407. doi: 10.21037/qims-20-1201.
本文引用的文献
1
NCCN Guidelines Insights: Breast Cancer, Version 1.2017.NCCN 指南解读：乳腺癌，第 1.2017 版。
J Natl Compr Canc Netw. 2017 Apr;15(4):433-451. doi: 10.6004/jnccn.2017.0044.
2
Analysis of molecular markers as predictive factors of lymph node involvement in breast carcinoma.分析分子标志物作为乳腺癌淋巴结受累的预测因素
Oncol Lett. 2017 Jan;13(1):488-496. doi: 10.3892/ol.2016.5438. Epub 2016 Nov 28.
3
21-Gene Recurrence Score and Locoregional Recurrence in Node-Positive/ER-Positive Breast Cancer Treated With Chemo-Endocrine Therapy.21基因复发评分与接受化疗-内分泌治疗的淋巴结阳性/雌激素受体阳性乳腺癌的局部区域复发
J Natl Cancer Inst. 2017 Jan 25;109(4). doi: 10.1093/jnci/djw259. Print 2017 Jan.
4
The clinical implication of the number of lymph nodes harvested during sentinel lymph node biopsy and its effects on survival outcome in patients with node-negative breast cancer.前哨淋巴结活检时获取的淋巴结数量的临床意义及其对淋巴结阴性乳腺癌患者生存结局的影响。
Am J Surg. 2017 Oct;214(4):726-732. doi: 10.1016/j.amjsurg.2016.10.019. Epub 2016 Nov 30.
5
Axillary Nodal Management Following Neoadjuvant Chemotherapy: A Review.腋窝淋巴结管理：新辅助化疗后的回顾。
JAMA Oncol. 2017 Apr 1;3(4):549-555. doi: 10.1001/jamaoncol.2016.4163.
6
Locoregional Recurrence After Sentinel Lymph Node Dissection With or Without Axillary Dissection in Patients With Sentinel Lymph Node Metastases: Long-term Follow-up From the American College of Surgeons Oncology Group (Alliance) ACOSOG Z0011 Randomized Trial.前哨淋巴结转移患者行前哨淋巴结清扫术加或不加腋窝清扫术后的局部区域复发：美国外科医师学会肿瘤学组（联盟）ACOSOG Z0011随机试验的长期随访
Ann Surg. 2016 Sep;264(3):413-20. doi: 10.1097/SLA.0000000000001863.
7
The Extent of Axillary Surgery Is Associated With Breast Cancer-specific Survival in T1-2 Breast Cancer Patients With 1 or 2 Positive Lymph Nodes: A SEER-Population Study.腋窝手术范围与伴有1或2个阳性淋巴结的T1-2期乳腺癌患者的乳腺癌特异性生存相关：一项监测、流行病学和最终结果（SEER）人群研究
Medicine (Baltimore). 2016 Apr;95(14):e3254. doi: 10.1097/MD.0000000000003254.
8
Extra-nodal extension of sentinel lymph node metastasis is a marker of poor prognosis in breast cancer patients: A systematic review and an exploratory meta-analysis.前哨淋巴结转移的结外扩展是乳腺癌患者预后不良的一个标志物：一项系统评价和探索性荟萃分析。
Eur J Surg Oncol. 2016 Jul;42(7):919-25. doi: 10.1016/j.ejso.2016.02.259. Epub 2016 Mar 10.
9
Validation of the IHC4 Breast Cancer Prognostic Algorithm Using Multiple Approaches on the Multinational TEAM Clinical Trial.在跨国TEAM临床试验中使用多种方法对IHC4乳腺癌预后算法进行验证。
Arch Pathol Lab Med. 2016 Jan;140(1):66-74. doi: 10.5858/arpa.2014-0599-OA.
10
Regional Nodal Irradiation in Early-Stage Breast Cancer.早期乳腺癌的区域淋巴结照射
N Engl J Med. 2015 Nov 5;373(19):1878-9. doi: 10.1056/NEJMc1510505.
Zotero 插件