de Meric de Bellefon Maïlys, Lemanski Claire, Ducteil Angélique, Fenoglietto Pascal, Azria David, Bourgier Celine
Institut Régional du Cancer de Montpellier (ICM), Montpellier, France.
Institut de Recherche en Cancérologie de Montpellier (IRCM), INSERM U1194, Montpellier, France.
Front Oncol. 2018 Apr 4;8:84. doi: 10.3389/fonc.2018.00084. eCollection 2018.
Systemic cancer therapies take into account breast cancer (BC) heterogeneity by targeting pathways specifically involved in some BC subtypes. On the other hand, BC intrinsic radiosensitivity is poorly understood and studied. Hence, radiotherapy personalization in BC is still "work in progress". In this review, we will summarize the existing data on the management of axillary lymph nodes in BC, the impact of BC radiotherapy on axillary management, the indications for axillary radiotherapy, and biomarkers to predict patients' outcome (tumor control and late toxicities) after axillary irradiation.
全身性癌症治疗通过靶向某些乳腺癌（BC）亚型特有的信号通路来考虑乳腺癌的异质性。另一方面，BC的内在放射敏感性却鲜为人知且研究较少。因此，BC放疗的个性化仍在“进行中”。在本综述中，我们将总结关于BC腋窝淋巴结管理的现有数据、BC放疗对腋窝管理的影响、腋窝放疗的适应症以及预测腋窝放疗后患者结局（肿瘤控制和晚期毒性）的生物标志物。
