Migita Kiyoshi, Tsuji Yoshika, Hisatomi Keiko, Shigeno Riyoko, Izumi Yasumori, Iwanaga Nozomi, Koga Tomohiro
a Department of Rheumatology and Clinical Research Center , Nagasaki Medical Center , Omura, Nagasaki , Japan.
b Department of Respiratory Medicine , Nagasaki Medical Center , Omura, Nagasaki , Japan.
Mod Rheumatol. 2017 Nov;27(6):1079-1082. doi: 10.3109/14397595.2015.1059008. Epub 2015 Jul 20.
We report a case involving a 68-year-old woman with rheumatoid arthritis (RA) with acute exacerbated interstitial lung disease (ILD) during certolizumab pegol maintenance therapy. She recovered quickly with steroid pulse therapy and was discharged without deterioration of basal pulmonary function. Immunoblot analysis demonstrated the circulating cleaved interleukin-1β at the phase of acute exacerbation of RA-associated ILD (RA-ILD) in this patient. The findings from this case suggested that the Nod-like receptor pyrin domain-containing protein 3 inflammasome is implicated in acute RA-ILD exacerbation.
我们报告了一例病例，患者为一名68岁患有类风湿性关节炎（RA）的女性，在聚乙二醇化赛妥珠单抗维持治疗期间出现急性加重的间质性肺疾病（ILD）。她通过类固醇冲击疗法迅速康复，出院时基础肺功能未恶化。免疫印迹分析显示，该患者在类风湿性关节炎相关间质性肺疾病（RA-ILD）急性加重期循环中存在裂解的白细胞介素-1β。该病例的研究结果表明，含Nod样受体吡啉结构域蛋白3炎性小体与RA-ILD急性加重有关。
