Andronache Iulia-Tania, Şuţa Victoria-Cristina, Şuţa Maria, Ciocodei Sabina-Livia, Vladareanu Liliana, Nicoara Alina Doina, Arghir Oana Cristina
Doctoral School of Medicine, "Ovidius" University of Constanta, 900470 Constanta, Romania.
Department of Rheumatology, Internal Medicine Clinic, "Dr. Alexandru Gafencu" Military Emergency Hospital Constanta, 900527 Constanta, Romania.
Biomedicines. 2023 Jun 19;11(6):1755. doi: 10.3390/biomedicines11061755.
It is well known that rheumatoid arthritis (RA) patients are at an increased risk of developing non-infectious pulmonary complications, especially interstitial lung disease (ILD); however, the clinician must keep in mind that lung disease could not only be a manifestation of the underlying condition, but also a consequence of using disease-modifying therapies. New-onset ILD or ILD worsening has also been reported as a possible consequence of both conventional disease-modifying antirheumatic drugs (DMARDs) and biologic agents. This study is a narrative review of the current literature regarding the potential risk of developing interstitial lung disease along with the administration of specific drugs used in controlling rheumatoid arthritis. Its purpose is to fill knowledge gaps related to this challenging patient cohort by addressing various aspects of the disease, including prevalence, disease features, treatment strategies, and patient outcomes.
众所周知,类风湿关节炎(RA)患者发生非感染性肺部并发症的风险增加,尤其是间质性肺疾病(ILD);然而,临床医生必须牢记,肺部疾病不仅可能是潜在疾病的表现,也可能是使用改善病情疗法的结果。新发ILD或ILD病情恶化也被报道为传统改善病情抗风湿药物(DMARDs)和生物制剂的可能后果。本研究是一篇叙述性综述,涉及使用控制类风湿关节炎的特定药物时发生间质性肺疾病的潜在风险的当前文献。其目的是通过探讨该疾病的各个方面,包括患病率、疾病特征、治疗策略和患者预后,来填补与这一具有挑战性的患者群体相关的知识空白。