ABO血型作为动脉血栓形成中血小板聚糖修饰的模型
ABO Blood Group as a Model for Platelet Glycan Modification in Arterial Thrombosis.
作者信息
Zhong Ming, Zhang Hanrui, Reilly John P, Chrisitie Jason D, Ishihara Mayumi, Kumagai Tadahiro, Azadi Parastoo, Reilly Muredach P
机构信息
From the Cardiology Division, Department of Medicine, Cardiovascular Institute (M.Z., H.Z., M.P.R.) and Pulmonology, Allergy, and Critical Care Division, Department of Medicine (J.P.R., J.D.C.), Perelman School of Medicine, University of Pennsylvania, Philadelphia; and Complex Carbohydrate Research Center, University of Georgia, Athens (M.I., T.K., P.A.).
出版信息
Arterioscler Thromb Vasc Biol. 2015 Jul;35(7):1570-8. doi: 10.1161/ATVBAHA.115.305337. Epub 2015 Jun 4.
ABO blood groups have long been associated with cardiovascular disease, thrombosis, and acute coronary syndromes. Many studies over the years have shown type O blood group to be associated with lower risk of cardiovascular disease than non-type O blood groups. However, the mechanisms underlying this association remain unclear. Although ABO blood group is associated with variations in concentrations of circulating von Willebrand Factor and other endothelial cell adhesion molecules, ABO antigens are also present on several platelet surface glycoproteins and glycosphingolipids. As we highlight in this platelet-centric review, these glycomic modifications may affect platelet function in arterial thrombosis. More broadly, improving our understanding of the role of platelet glycan modifications in acute coronary syndromes may inform future diagnostics and therapeutics for cardiovascular diseases.
ABO血型长期以来一直与心血管疾病、血栓形成和急性冠状动脉综合征相关。多年来的许多研究表明，与非O型血相比，O型血与较低的心血管疾病风险相关。然而，这种关联背后的机制仍不清楚。虽然ABO血型与循环血管性血友病因子和其他内皮细胞粘附分子的浓度变化有关，但ABO抗原也存在于几种血小板表面糖蛋白和糖鞘脂上。正如我们在这篇以血小板为中心的综述中所强调的，这些糖基修饰可能会影响动脉血栓形成中的血小板功能。更广泛地说，增进我们对血小板聚糖修饰在急性冠状动脉综合征中的作用的理解，可能会为未来心血管疾病的诊断和治疗提供依据。
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