Clark Peter, Wu Olivia
Department of Transfusion Medicine, East of Scotland Blood Transfusion Centre, Ninewells Hospital and Medical School, Dundee, DD1 9SY, UK.
Future Cardiol. 2011 Mar;7(2):191-201. doi: 10.2217/fca.10.191.
ABO(H) antigens are expressed on red cells and on von Willebrand factor. An association between groups other than O and thrombosis exists: an effect that is predominantly mediated by von Willebrand factor. Overall, the risk of venous thrombosis associated with non-O has been estimated at 1.75-fold, with a higher risk (∼ 2.4-fold) in those with the least O(H) antigen (a combined group of A(1)A(1)/A(1)B/BB). Preliminary evidence also suggests that blood group may influence the venous thromboembolism risk associated with factor V Leiden. Overall, ABO(H) has a more modest effect on arterial disease, with a consistent effect observed in peripheral vascular disease and no influence evident with angina. A modest effect on myocardial infarction and stroke has been reported in some but not all studies. The potential mechanisms whereby blood group influences thrombosis, the limitations of current evidence and the current and future role of blood groups in identifying those at risk of arterial and venous disease is discussed.
ABO(H)抗原在红细胞和血管性血友病因子上表达。非O血型与血栓形成之间存在关联：这种效应主要由血管性血友病因子介导。总体而言，与非O血型相关的静脉血栓形成风险估计为1.75倍，在O(H)抗原最少的人群（A(1)A(1)/A(1)B/BB组合人群）中风险更高（约2.4倍）。初步证据还表明，血型可能影响与凝血因子V莱顿突变相关的静脉血栓栓塞风险。总体而言，ABO(H)对动脉疾病的影响较小，在外周血管疾病中观察到一致的效应，而在心绞痛中则无明显影响。一些但并非所有研究都报道了其对心肌梗死和中风有一定影响。本文讨论了血型影响血栓形成的潜在机制、现有证据的局限性以及血型在识别动脉和静脉疾病风险人群方面的当前和未来作用。
