Luo Xiangjian, Yu Xinfang, Liu Sufang, Deng Qipan, Liu Xiaolan, Peng Songling, Li Hongde, Liu Jikai, Cao Ya
Cancer Research Institute, Xiangya School of Medicine, Central South University, Changsha, Hunan, P.R. China.
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan, P.R. China.
Oncol Rep. 2015 Aug;34(2):547-54. doi: 10.3892/or.2015.4029. Epub 2015 Jun 4.
The WHO clearly identifies tumors as a curable or a chronic disease. The use of natural agents in cancer prevention and therapy is currently playing an important role. Our laboratory has been investigating various natural phenolic compounds, including grifolin, neoalbaconol and epigallocatechin-3-gallate (EGCG). In the present review, we focus on the anticancer activities and the molecular mechanisms of these compounds. Grifolin, a secondary metabolite isolated from the mushroom Albatrellus confluens, has been shown to inhibit cell growth and induce cell cycle arrest in multiple cancer cell lines by targeting extracellular signal-regulated kinase 1 or by upregulating death-associated protein kinase 1 (DAPK1) via p53. We also demonstrated that neoalbaconol, a novel small-molecular compound with a drimane-type sesquiterpenoid structure obtained from Albatrellus confluens, regulates cell metabolism by targeting 3-phosphoinositide-dependent protein kinase 1 (PDK1) and inhibits cancer cell growth. EGCG, a well known catechin found in tea, has gained much attention for its anticancer effects. Previously, we found that it regulates EBV lytic infection through the phosphoinositide-3 kinase/Akt (PI3K/Akt) and mitogen-activated protein kinase (MAPK) pathways in EBV-positive cancer cells. Therefore, these natural agents could be used as potential leading compounds in the prevention of tumor progression and/or EBV-related cancer.
世界卫生组织明确将肿瘤认定为可治愈疾病或慢性病。天然物质在癌症预防和治疗中的应用目前正发挥着重要作用。我们实验室一直在研究各种天然酚类化合物，包括茯苓酸、新茯苓醇和表没食子儿茶素-3-没食子酸酯（EGCG）。在本综述中，我们重点关注这些化合物的抗癌活性及其分子机制。茯苓酸是从融合白蘑中分离出的一种次生代谢产物，已显示其通过靶向细胞外信号调节激酶1或经由p53上调死亡相关蛋白激酶1（DAPK1），从而抑制多种癌细胞系中的细胞生长并诱导细胞周期停滞。我们还证明，新茯苓醇是一种从融合白蘑中获得的具有菖蒲烷型倍半萜结构的新型小分子化合物，它通过靶向3-磷酸肌醇依赖性蛋白激酶1（PDK1）来调节细胞代谢并抑制癌细胞生长。EGCG是茶叶中一种广为人知的儿茶素，其抗癌作用备受关注。此前，我们发现它通过磷酸肌醇-3激酶/蛋白激酶B（PI3K/Akt）和丝裂原活化蛋白激酶（MAPK）途径调节EB病毒的裂解感染，在EB病毒阳性癌细胞中发挥作用。因此，这些天然物质可作为预防肿瘤进展和/或EB病毒相关癌症的潜在先导化合物。
