Xiao Hui-Hui, Dai Yi, Wong Man-Sau, Yao Xin-Sheng
a Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University , Guangzhou , China.
J Asian Nat Prod Res. 2015;17(6):625-32. doi: 10.1080/10286020.2015.1046448. Epub 2015 Jun 5.
Two new phenylpropanoids, samwirin (1) and samwiphenol (2), and a new sesquiterpenoid, 2β,4β,10α-trihydroxy-1αH,5βH-guaia-6-ene (3), together with six known compounds were isolated from the bioactive fraction of Sambucus williamsii Hance. Their structures including the absolute configurations were characterized on the basis of extensive 1D, 2D-NMR, MS, and CD spectral data. In vitro proliferation effects of all compounds on osteoblast-like UMR 106 cells were examined. Compounds 1, 4-9 significantly promoted cell proliferation. Compounds 5, 6, and 8 increased osteoblastic cell numbers separately by 24.3%, 25.2%, and 29.1% at 10(-10) M, 10(-10) M, and 10(-8) M, respectively.
从接骨木的生物活性部分分离出两种新的苯丙素类化合物，接骨木苷（1）和接骨木酚（2），以及一种新的倍半萜类化合物，2β,4β,10α-三羟基-1αH,5βH-愈创木-6-烯（3），同时还分离出六种已知化合物。基于广泛的一维、二维核磁共振、质谱和圆二色谱光谱数据对它们的结构（包括绝对构型）进行了表征。检测了所有化合物对成骨样UMR 106细胞的体外增殖作用。化合物1、4 - 9显著促进细胞增殖。化合物5、6和8在浓度分别为10(-10) M、10(-10) M和10(-8) M时，分别使成骨细胞数量增加了24.3%、25.2%和29.1%。
