小儿中枢神经系统肿瘤治疗的远期效应
Late Effects of Treatment of Pediatric Central Nervous System Tumors.
作者信息
Roddy Erika, Mueller Sabine
机构信息
School of Medicine, University of California, San Francisco, CA, USA.
Department of Neurology, University of California, San Francisco, CA, USA Department of Pediatrics, University of California, San Francisco, CA, USA Department of Neurosurgery, University of California, San Francisco, CA, USA
出版信息
J Child Neurol. 2016 Feb;31(2):237-54. doi: 10.1177/0883073815587944. Epub 2015 Jun 4.
Central nervous system tumors represent the most common solid malignancy in childhood. Improvement in treatment approaches have led to a significant increase in survival rates, with over 70% of children now surviving beyond 5 years. As more and more children with CNS tumors have longer survival times, it is important to be aware of the long-term morbidities caused not only by the tumor itself but also by tumor treatment. The most common side effects including poor neurocognition, endocrine dysfunction, neurological and vascular late effects, as well as secondary malignancies, are discussed within this article.
中枢神经系统肿瘤是儿童期最常见的实体恶性肿瘤。治疗方法的改进使生存率显著提高，现在超过70%的儿童存活时间超过5年。随着越来越多的中枢神经系统肿瘤患儿存活时间延长，了解不仅由肿瘤本身而且由肿瘤治疗引起的长期发病情况很重要。本文讨论了最常见的副作用，包括神经认知功能差、内分泌功能障碍、神经和血管晚期效应以及继发性恶性肿瘤。
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