Xu Rengyi, DeMauro Sara B, Feng Rui
Department of Biostatistics and Epidemiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
Division of Neonatology, Perelman School of Medicine at the University of Pennsylvania and The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
J Asthma Allergy. 2015 May 25;8:51-61. doi: 10.2147/JAA.S80245. eCollection 2015.
This study aimed to examine the separate effects of maternal and paternal history on the onset of asthma in children and evaluate the relationship between age of asthma onset in parents and risk of asthma in their children.
We used data from the third National Health and Nutrition Examination Survey. We developed new continuous standardized scores for survey data to quantify parental history that incorporated both the occurrence of asthma and the age at onset, and associated these scores with asthma risk in the children. The association analysis was adjusted for sex and obesity status.
Children with maternal history have elevated asthma risk (hazard ratio of 3.71, 95% CI: 1.19-11.60) than those without, and those whose mothers had earlier age of onset have increased risk of asthma compared to those whose mothers had later age of onset. On the contrary, paternal history had a relatively smaller effect that may be only detectable in larger samples (hazard ratio of 2.17, 95% CI: 0.69-6.79).
Maternal asthma history was strongly associated with the onset of asthma in the second generation, and children whose mother had an earlier age of onset had an increased risk of 3.71. For an approximately 10-year decrease in mother's age at onset of asthma, the risk of asthma for the offspring increased by 1.37-fold. Using our new risk scores led to smaller standard errors and thus more precise estimates than using a binary indicator.
本研究旨在探讨母亲和父亲的病史对儿童哮喘发病的单独影响，并评估父母哮喘发病年龄与子女哮喘风险之间的关系。
我们使用了第三次全国健康与营养检查调查的数据。我们为调查数据开发了新的连续标准化分数，以量化包含哮喘发生情况和发病年龄的父母病史，并将这些分数与儿童的哮喘风险相关联。关联分析对性别和肥胖状况进行了校正。
有母亲病史的儿童比没有的儿童哮喘风险更高（风险比为3.71，95%置信区间：1.19 - 11.60），并且母亲发病年龄早的儿童比母亲发病年龄晚的儿童哮喘风险增加。相反，父亲病史的影响相对较小，可能仅在更大样本中可检测到（风险比为2.17，95%置信区间：0.69 - 6.79）。
母亲的哮喘病史与第二代哮喘发病密切相关，母亲发病年龄早的儿童哮喘风险增加3.71倍。母亲哮喘发病年龄每大约降低10岁，后代哮喘风险增加1.37倍。使用我们新的风险分数比使用二元指标导致更小的标准误差，从而估计更精确。
