Ettinger Kyle S, Yildirim Yavuz, Weingarten Toby N, Van Ess James M, Viozzi Christopher F, Arce Kevin
Resident, Division of Oral and Maxillofacial Surgery, Department of Surgery, Mayo Clinic and Mayo College of Medicine, Rochester, MN.
Resident, Division of Oral and Maxillofacial Surgery, Department of Surgery, Mayo Clinic and Mayo College of Medicine, Rochester, MN.
J Oral Maxillofac Surg. 2016 Jan;74(1):130-8. doi: 10.1016/j.joms.2015.05.025. Epub 2015 May 28.
To evaluate the impact of induced hypotensive anesthesia on length of hospital stay (LOS) for patients undergoing maxillary Le Fort I osteotomy in isolation or in combination with mandibular orthognathic surgery.
A retrospective cohort study design was implemented and patients undergoing a Le Fort I osteotomy as a component of orthognathic surgery at the Mayo Clinic from 2010 through 2014 were identified. The primary predictor variable was the presence of induced hypotensive anesthesia during orthognathic surgery. Hypotensive anesthesia was defined as at least 10 consecutive minutes of a mean arterial pressure no higher than 60 mmHg documented within the anesthetic record. The primary outcome variable was LOS in hours after completion of orthognathic surgery. The secondary outcome variable was the duration of surgery in hours. Multiple covariates also abstracted included patient age, patient gender, American Society of Anesthesiologists score, complexity of surgical procedure, and volume of intraoperative fluids administered during surgery. Univariable and multivariable models were developed to evaluate associations between the primary predictor variable and covariates relative to the primary and secondary outcome variables.
A total of 117 patients were identified undergoing Le Fort I orthognathic surgery in isolation or in combination with mandibular surgery. Induced hypotensive anesthesia was significantly associated with shortened LOS (odds ratio [OR] = 0.33; 95% confidence interval [CI], 0.12-0.88; P = .026) relative to patients with normotensive regimens. This association between hypotensive anesthesia and LOS remained statistically significant in a subgroup analysis of 47 patients in whom isolated Le Fort I surgery was performed (OR = 0.13; 95% CI, 0.03-0.62; P = .010). Induced hypotensive anesthesia was not statistically associated with shorter duration of surgery.
Induced hypotensive anesthesia represents a potential factor that minimizes postoperative LOS for patients undergoing routine maxillary orthognathic surgery alone or in combination with mandibular procedures. Hypotensive anesthesia does not appear to be effective in minimizing the duration of surgery within this same patient population.
评估控制性低血压麻醉对单纯接受上颌Le Fort I型截骨术或联合下颌正颌手术患者住院时间(LOS)的影响。
采用回顾性队列研究设计,确定2010年至2014年在梅奥诊所接受作为正颌手术一部分的Le Fort I型截骨术的患者。主要预测变量是正颌手术期间是否使用控制性低血压麻醉。控制性低血压麻醉定义为麻醉记录中记录的平均动脉压不高于60 mmHg至少连续10分钟。主要结局变量是正颌手术后以小时为单位的住院时间。次要结局变量是以小时为单位的手术时长。还提取了多个协变量,包括患者年龄、患者性别、美国麻醉医师协会评分、手术复杂性以及手术期间输注的术中液体量。建立单变量和多变量模型以评估主要预测变量和协变量相对于主要和次要结局变量之间的关联。
共确定117例患者接受了单纯或联合下颌手术的Le Fort I型正颌手术。与接受正常血压方案的患者相比,控制性低血压麻醉与缩短的住院时间显著相关(优势比[OR]=0.33;95%置信区间[CI],0.12 - 0.88;P = 0.026)。在对47例进行单纯Le Fort I手术的患者的亚组分析中,控制性低血压麻醉与住院时间之间的这种关联仍具有统计学意义(OR = 0.13;95% CI,0.03 - 0.62;P = 0.010)。控制性低血压麻醉与较短的手术时长无统计学关联。
控制性低血压麻醉是一个潜在因素,可使单纯接受常规上颌正颌手术或联合下颌手术的患者术后住院时间最短。在同一患者群体中,控制性低血压麻醉似乎对缩短手术时长无效。