He C, Mao T, Feng Y, Song T, Qin C, Yan R, Feng P
Department of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Department of Clinical Nutrition, 302 Hospital of PLA, Beijing, China.
Lupus. 2015 Nov;24(13):1370-6. doi: 10.1177/0961203315588970. Epub 2015 Jun 5.
Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder that affects a variety of organ systems. Anti-dsDNA Abs and complement factors have been used as indicators of lupus activity for more than 50 years. A novel indicator of activation in SLE is reported in this paper. Anti-collagen type II (CII) Ab was obviously elevated in patients with SLE compared to those patients with ankylosing spondylitis (AS) and healthy controls (HCs). Anti-CII-Ab-positive patients with SLE showed significantly higher levels of serum IgG and higher titers of ANA but lower levels of C3 and C4 than controls. A positive correlation was demonstrated between anti-CII Ab and serum IgG in SLE patients (r = 0.50, p < 0.0001). The negative correlations of anti-CII Ab with C3 and C4 were observed in SLE patients (r = -0.36, p = 0.0013; r = -0.37, p = 0.0006, respectively). The reduced anti-CII Ab level was accompanied by decreased level of serum IgG and increased levels of C3 and C4 after regular treatment. Therefore, anti-CII Ab could be a novel indicator for monitoring activity of SLE.
系统性红斑狼疮（SLE）是一种影响多种器官系统的慢性自身免疫性疾病。抗双链DNA抗体和补体因子已被用作狼疮活动指标50多年。本文报道了一种SLE激活的新指标。与强直性脊柱炎（AS）患者和健康对照（HC）相比，SLE患者的抗II型胶原（CII）抗体明显升高。SLE抗CII抗体阳性患者的血清IgG水平显著更高，ANA滴度更高，但C3和C4水平低于对照组。SLE患者中抗CII抗体与血清IgG之间呈正相关（r = 0.50，p < 0.0001）。在SLE患者中观察到抗CII抗体与C3和C4呈负相关（分别为r = -0.36，p = 0.0013；r = -0.37，p = 0.0006）。经过正规治疗后，抗CII抗体水平降低，同时血清IgG水平降低，C3和C4水平升高。因此，抗CII抗体可能是监测SLE活动的一个新指标。
