Malipeddi Mahima, Lakhani Chirag, Chhabra Mohit, Paira Priyankar, Vidya R
Pharmaceutical Chemistry Division, School of Advance Sciences, VIT University, Vellore 632014, Tamilnadu, India.
Pharmaceutical Chemistry Division, School of Advance Sciences, VIT University, Vellore 632014, Tamilnadu, India.
Bioorg Med Chem Lett. 2015 Aug 1;25(15):2892-6. doi: 10.1016/j.bmcl.2015.05.063. Epub 2015 May 30.
A series of ruthenium-quinolinol complexes were synthesized using a simple and effective pathway and their in vitro antibacterial activity against various resistant gram-positive and gram-negative bacteria were evaluated. It was established that compound [(η6-pcymene)RuCl(κ2-O,N-5,7-dibromo-HyQ)]·Cl (3b) & [(η6-pcymene)RuCl(κ2-O,N-5,7-dibromo-HyQ)]·Cl (3e) were significantly active against Staphylococcus aureus, Escherichia coli, Bacillus subtilis &Salmonella sp. The structures of the new compounds were elucidated by the analysis of spectroscopic data. The stability of complex [(η6-pcymene)RuCl(κ2-O,N-5,7-dibromo-HyQ)]·Cl (3b) was measured by UV spectroscopy & time dependent NMR spectroscopy. Compound 3b also shows remarkable fluorescence.
通过一种简单有效的方法合成了一系列钌-喹啉醇配合物，并评估了它们对各种耐药革兰氏阳性菌和革兰氏阴性菌的体外抗菌活性。已确定化合物[(η6-对异丙基苯)RuCl(κ2-O,N-5,7-二溴-HyQ)]·Cl (3b)和[(η6-对异丙基苯)RuCl(κ2-O,N-5,7-二溴-HyQ)]·Cl (3e)对金黄色葡萄球菌、大肠杆菌、枯草芽孢杆菌和沙门氏菌具有显著活性。通过光谱数据分析阐明了新化合物的结构。通过紫外光谱和时间相关核磁共振光谱测定了配合物[(η6-对异丙基苯)RuCl(κ2-O,N-5,7-二溴-HyQ)]·Cl (3b)的稳定性。化合物3b还显示出显著的荧光。
