Department of Anatomic Pathology, Cleveland Clinic, Cleveland, OH, USA
Department of Anatomic Pathology, Cleveland Clinic, Cleveland, OH, USA.
Gastroenterol Rep (Oxf). 2015 Aug;3(3):222-7. doi: 10.1093/gastro/gov020. Epub 2015 Jun 6.
Inflammatory/hyperplastic small-bowel polyps (SBPs) occur either sporadically or in patients with a polyposis syndrome; however, comparison between these two settings of the histological features of SBPs has not been reported and the etiology of sporadic inflammatory/hyperplastic SBPs remains unclear.
Twenty-eight cases of sporadic inflammatory/hyperplastic SBPs and nine cases of syndromic SBPs were retrieved from the Department of Anatomic Pathology at the Cleveland Clinic. Clinico-demographics and histological features were compared between the two groups.
Patients with syndromic inflammatory/hyperplastic SBPs were younger (48 vs. 63 years; P = 0.007) and had higher rates of hemorrhagic telangiectasia (55.6% vs. 0%; P = 0.000), gastric polyps (87.5% vs. 21.4%; P = 0.001), and family history of colon cancer (62.5% vs. 11.1%; P = 0.014). Sporadic cases were more frequently associated with gastro-esophageal reflux (35.7% vs. 0%; P = 0.079) and anti-reflux medication use (55.6% vs. 11.1%; P = 0.026). Histologically, the syndromic SBPs were more often of pure intestinal type (45.4% vs. 3.8%; P = 0.005) and had prominent vessels (81.8% vs. 42.3%; P = 0.036).
Patients with syndromic SBPs are younger and have higher rates of hemorrhagic telangiectasia, gastric polyps, and family history of colon cancer. Histologically, syndromic inflammatory/hyperplastic SBPs are more likely to be of pure intestinal type and to have prominent vessels.
炎症/增生性小肠息肉（SBPs）可偶发或发生于息肉病综合征患者中；然而，尚未有文献报道这两种情况下 SBPs 的组织学特征，且偶发性炎症/增生性 SBPs 的病因仍不清楚。
从克利夫兰诊所的解剖病理学系收集了 28 例偶发性炎症/增生性 SBPs 和 9 例综合征性 SBPs 病例。比较了两组患者的临床病理特征。
综合征性炎症/增生性 SBPs 患者更年轻（48 岁 vs. 63 岁；P=0.007），且出血性毛细血管扩张症（55.6% vs. 0%；P=0.000）、胃息肉（87.5% vs. 21.4%；P=0.001）和结肠癌家族史（62.5% vs. 11.1%；P=0.014）的发生率更高。偶发性病例更常与胃食管反流（35.7% vs. 0%；P=0.079）和抗反流药物使用（55.6% vs. 11.1%；P=0.026）相关。组织学上，综合征性 SBPs 更常为单纯肠型（45.4% vs. 3.8%；P=0.005），且有明显的血管（81.8% vs. 42.3%；P=0.036）。
综合征性 SBPs 患者更年轻，且出血性毛细血管扩张症、胃息肉和结肠癌家族史的发生率更高。组织学上，综合征性炎症/增生性 SBPs 更可能为单纯肠型，且有明显的血管。
