Pontes Isabelle Ea, Afra Karine F, Silva José R, Borges Paulo Sn, Clough Geraldine F, Alves João Gb
Mother and Child Unit, Instituto de Medicina Integral Prof. Fernando Figueira (IMIP), Rua dos Coelhos, 300, 50070-550 Boa Vista Recife, Pernambuco Brazil.
Faculty of Medicine, University of Southampton, Southampton, UK.
Diabetol Metab Syndr. 2015 Mar 28;7:27. doi: 10.1186/s13098-015-0017-4. eCollection 2015.
To compare microvascular reactivity assessed in the skin using laser Doppler fluximetry (LDF) in women with gestational diabetes mellitus (GDM) and gestational age-matched control during pregnancy.
110 pregnant women at ~33 weeks gestation participated in the study. Skin microvascular reactivity was evaluated by LDF, at rest, during the response to brief arterial occlusion (post occlusive hyperaemic response) and during sympathetically mediated vasoconstrictor response to deep inspiratory breath hold.
No statistically significant differences were found in the microvascular variables studied (resting and maximum rate flux, post-ischaemic reactive hyperaemia and deep inspiratory breath holds) between +GDM and -GDM groups women. In women with GDM there was a negative correlation between resting flux and the response to the oral glucose tolerance test (OGTT), r = -0.282 (p = 0.037). There was also a negative correlation between the response to the OGTT and the sympathetically mediated constrictor response to inspiratory breath holds (r = -.298, p = .030) but not in women with GDM (r = .102, r = .468).
Attenuated microvascular reactivity as an early marker of endothelial dysfunction is not present in women with GDM when assessed during pregnancy.
比较妊娠期糖尿病（GDM）女性与孕周匹配的对照组女性在孕期使用激光多普勒血流仪（LDF）评估的皮肤微血管反应性。
110名孕周约33周的孕妇参与了该研究。通过LDF评估皮肤微血管反应性，分别在静息状态、短暂动脉闭塞反应期间（缺血后充血反应）以及交感神经介导的深吸气屏气血管收缩反应期间进行评估。
在研究的微血管变量（静息和最大血流率、缺血后反应性充血和深吸气屏气）方面，GDM组和非GDM组女性之间未发现统计学上的显著差异。在GDM女性中，静息血流与口服葡萄糖耐量试验（OGTT）反应之间存在负相关，r = -0.282（p = 0.037）。OGTT反应与交感神经介导的吸气屏气收缩反应之间也存在负相关（r = -0.298，p = 0.030），但在GDM女性中不存在这种相关性（r = 0.102，p = 0.468）。
在孕期评估时，GDM女性不存在作为内皮功能障碍早期标志物的微血管反应性减弱情况。
