Ezure T, Yagi E, Amano S, Matsuzaki K
Shiseido Research Center, Kanagawa, Japan.
St Marianna University School of Medicine, Kanagawa, Japan.
Skin Res Technol. 2016 May;22(2):152-7. doi: 10.1111/srt.12242. Epub 2015 Jun 7.
BACKGROUND/PURPOSE: Facial skin must be linked to underlying structures to maintain facial morphology and prevent sagging, but the mechanism of facial skin retention is largely unknown. We aimed to elucidate this mechanism.
Twenty-two cheek skin specimens (age range: 10s-60s, both genders) were observed histologically. And 30 cheek of healthy Japanese volunteers (age range: 30s-50s, female) was photographed and the severity of sagging was graded. Dermal layer morphology was observed non-invasively with ultrasound. Skin-retaining force was measured with a Cutometer MPA 580(®) , and sagging severity was evaluated by grading criteria.
Histological observation revealed characteristic convex structures at the bottom of the dermal layer. Non-invasive study showed that the depth of the convex structures, measured by ultrasonography, was significantly negatively related to the ratio of viscoelastic to elastic distention (Uv/Ue) and positively related to the ratio of elastic recovery to total deformation (Ur/Uf) at the cheek of female volunteers, measured by cutometer. It was also negatively related to sagging severity. Further, Ur/Uf was negatively and Uv/Ue was positively related to sagging severity.
Characteristic convex structures at the bottom of the dermal layer serve as anchoring structures to maintain skin morphology.
背景/目的：面部皮肤必须与深层结构相连以维持面部形态并防止下垂，但面部皮肤固定的机制在很大程度上尚不清楚。我们旨在阐明这一机制。
对22个脸颊皮肤标本（年龄范围：10多岁至60多岁，男女均有）进行组织学观察。对30名健康日本志愿者（年龄范围：30多岁至50多岁，女性）的脸颊进行拍照，并对下垂严重程度进行分级。用超声非侵入性观察真皮层形态。用Cutometer MPA 580(®)测量皮肤固定力，并根据分级标准评估下垂严重程度。
组织学观察显示真皮层底部有特征性的凸起结构。非侵入性研究表明，通过超声测量，凸起结构的深度与女性志愿者脸颊处粘弹性扩张与弹性扩张的比率（Uv/Ue）呈显著负相关，与弹性恢复与总变形的比率（Ur/Uf）呈正相关，该比率由皮肤弹性测量仪测量。它也与下垂严重程度呈负相关。此外，Ur/Uf与下垂严重程度呈负相关，Uv/Ue与下垂严重程度呈正相关。
真皮层底部的特征性凸起结构作为锚定结构来维持皮肤形态。
