Shiseido Research Center, 2-2-1 Hayabuchi, Tsuzuki-ku, Yokohama-shi, Kanagawa, Japan.
Skin Res Technol. 2010 Aug;16(3):332-8. doi: 10.1111/j.1600-0846.2010.00438.x.
Subcutaneous adipose tissue lies just beneath the dermal layer, but the interaction between the two is not well understood. Recently, we showed that the subcutaneous adipose layer affects dermal properties in an obese rodent model.
To explore the influence of the subcutaneous adipose layer on dermal properties and morphology in humans.
Subcutaneous adipose mass was measured by ultrasound using a Prosound alpha 5, dermal elasticity was measured using an in vivo suction skin elasticity meter (Cutometer MPA 580, and sagging severity were evaluated morphologically using photograph-based grading criteria at the lower cheek in 70 Japanese female volunteers (age; 31-59, BMI; 17.1-36.2). The correlations among the results were examined.
Thickness of the subcutaneous adipose layer was significantly and negatively correlated with dermal elasticity parameters, i.e., elastic deformation, elastic deformation recovery, extensibility, total deformation recovery, ratio of viscoelasticity to elastic distention and overall elasticity, including creep and creep recovery. Furthermore, we investigated their influence on facial morphology, such as sagging. The subcutaneous adipose mass was significantly and positively correlated with sagging severity at the lower cheek (R=0.442, P<0.001), and there was a significant negative correlation between dermal elasticity and sagging severity (R=-0.358, P<0.01).
These results indicate that increment of subcutaneous adipose mass impairs dermal elasticity, which in turn exacerbates sagging severity.
皮下脂肪组织位于真皮层下方，但两者之间的相互作用尚未得到很好的理解。最近，我们发现肥胖啮齿动物模型中的皮下脂肪层会影响皮肤特性。
探索皮下脂肪层对人体皮肤特性和形态的影响。
使用 Prosound alpha 5 超声仪测量皮下脂肪量，使用体内负压皮肤弹性计（Cutometer MPA 580）测量皮肤弹性，使用基于照片的分级标准在下颌下部评估皮肤松弛的严重程度，共纳入 70 名日本女性志愿者（年龄 31-59 岁，BMI 为 17.1-36.2）。检验结果之间的相关性。
皮下脂肪层厚度与皮肤弹性参数，即弹性变形、弹性变形恢复、伸展性、总变形恢复、粘弹性与弹性扩张比以及整体弹性（包括蠕变和蠕变恢复）呈显著负相关。此外，我们还研究了它们对面部形态（如松弛）的影响。在下颌下部，皮下脂肪量与松弛严重程度呈显著正相关（R=0.442，P<0.001），而皮肤弹性与松弛严重程度呈显著负相关（R=-0.358，P<0.01）。
这些结果表明，皮下脂肪量的增加会损害皮肤弹性，从而加剧松弛的严重程度。
