Kashino Ikuko, Nanri Akiko, Kurotani Kayo, Akter Shamima, Yasuda Kazuki, Sato Masao, Hayabuchi Hitomi, Mizoue Tetsuya
Department of Epidemiology and Prevention, Center for Clinical Sciences, National Center for Global Health and Medicine, Toyama 1-21-1, Shinjuku-ku, Tokyo, 162-8655, Japan.
Department of Metabolic Disorder, Diabetes Research Center, National Center for Global Health and Medicine, Tokyo, Japan.
Nutr J. 2015 Jun 11;14:58. doi: 10.1186/s12937-015-0046-8.
Diet may influence disease risk by modulating adipokines. Although some foods and nutrients have been linked to circulating adipokine levels, little is known about the role of dietary patterns on adipokines. We investigated the association between major dietary patterns and circulating levels of adiponectin, leptin, resistin, visfatin, and plasminogen activator inhibitor-1 (PAI-1) in a working population.
The subjects were 509 employees (296 men and 213 women), aged 20 to 65 years, of two municipal offices. Serum adipokines were measured using a Luminex suspension bead-based multiplexed array. Dietary patterns were derived by using principal component analysis of the consumption of 52 food and beverage items, which were ascertained by a validated diet history questionnaire. Multiple regression analysis was performed to assess the association between dietary pattern scores and adipokine concentrations, with adjustment for potential confounders.
Three major dietary patterns were extracted: a Japanese, a Westernized breakfast, and a meat food patterns. Of these, we found significant, inverse associations of the Westernized breakfast pattern, which was characterized by higher intake of confectioneries, bread, and milk and yogurt but lower intake of alcoholic beverages and rice, with serum leptin and PAI-1 concentrations in a fully adjusted model (P for trend = 0.04 for both leptin and PAI-1). The other adipokines were not significantly associated with any dietary pattern.
The Westernized breakfast dietary pattern may be associated with lower circulating levels of leptin and PAI-1.
饮食可能通过调节脂肪因子影响疾病风险。尽管一些食物和营养素与循环脂肪因子水平有关，但饮食模式对脂肪因子的作用知之甚少。我们在一个工作人群中研究了主要饮食模式与脂联素、瘦素、抵抗素、内脂素和纤溶酶原激活物抑制剂-1（PAI-1）循环水平之间的关联。
研究对象为两个市政办公室的509名员工（296名男性和213名女性），年龄在20至65岁之间。使用基于Luminex悬浮微珠的多重检测阵列测量血清脂肪因子。通过对52种食品和饮料的消费情况进行主成分分析得出饮食模式，这些食品和饮料的消费情况通过一份经过验证的饮食史问卷确定。进行多元回归分析以评估饮食模式得分与脂肪因子浓度之间的关联，并对潜在混杂因素进行调整。
提取出三种主要饮食模式：日式、西式早餐和肉类饮食模式。其中，我们发现西式早餐模式（其特点是糖果、面包、牛奶和酸奶摄入量较高，但酒精饮料和米饭摄入量较低）与血清瘦素和PAI-1浓度在完全调整模型中有显著的负相关（瘦素和PAI-1的趋势P值均为0.04）。其他脂肪因子与任何饮食模式均无显著关联。
西式早餐饮食模式可能与较低的瘦素和PAI-1循环水平有关。
