Department of Nutritional Sciences, Faculty of Nutritional Sciences, Nakamura Gakuen University, 5-7-1 Befu, Jounan-Ku, Fukuoka, 814-0104, Japan.
Department of Metabolic Disorder, Diabetes Research Center, National Center for Global Health and Medicine, Tokyo, Japan.
Eur J Nutr. 2017 Dec;56(8):2497-2505. doi: 10.1007/s00394-016-1285-y. Epub 2016 Aug 2.
Increased iron storage, as measured by circulating ferritin, has been linked to an increased risk of various diseases including diabetes. We examined the association of circulating ferritin with serum adiponectin, leptin, resistin, plasminogen activator inhibitor-1 (PAI-1), and visfatin levels.
We conducted a cross-sectional study among 429 Japanese employees (284 men and 145 premenopausal women, mean age: 42.5 ± 10.5 years). Serum adipokines were measured using Luminex suspension bead-based multiplexed array, and serum ferritin was determined using a chemiluminescence immunoassay. Multivariable regression analysis was performed to calculate mean concentrations of adipokine according to the tertile of ferritin concentrations with adjustment for potential confounders.
Leptin and visfatin concentrations increased with increasing ferritin concentrations in men after multivariable adjustment of physical activity, smoking, alcohol use, and body mass index (P for trend = 0.02 and 0.01 for leptin and visfatin, respectively). Serum ferritin concentrations were inversely and significantly associated with adiponectin in women (P for trend = 0.01). Resistin and PAI-1 were not appreciably associated with ferritin concentration.
Increased iron storage may be associated with higher circulating concentrations of leptin and visfatin in men and with lower concentrations of adiponectin in women.
循环铁蛋白水平升高与多种疾病（包括糖尿病）风险增加有关，而循环铁蛋白水平升高代表铁储存增加。我们研究了循环铁蛋白与血清脂联素、瘦素、抵抗素、纤溶酶原激活物抑制剂-1（PAI-1）和内脂素水平之间的关系。
我们对 429 名日本员工（284 名男性和 145 名绝经前女性，平均年龄：42.5±10.5 岁）进行了横断面研究。采用 Luminex 悬浮珠基多重分析检测血清脂联素，采用化学发光免疫分析法检测血清铁蛋白。采用多变量回归分析，根据铁蛋白浓度三分位计算脂联素的平均浓度，调整潜在混杂因素。
在调整体力活动、吸烟、饮酒和体重指数等因素后，男性的瘦素和内脂素浓度随着铁蛋白浓度的增加而升高（瘦素和内脂素的趋势 P 值分别为 0.02 和 0.01）。女性的血清铁蛋白浓度与脂联素呈负相关且有统计学意义（趋势 P 值为 0.01）。抵抗素和 PAI-1 与铁蛋白浓度无明显相关性。
铁储存增加可能与男性循环瘦素和内脂素浓度升高以及女性脂联素浓度降低有关。
