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神经外科患者因术后出血进行的非计划性再次手术:单中心经验及文献综述

Unplanned Reoperations in Neurosurgical Patients Due to Postoperative Bleeding: A Single-Center Experience and Literature Review.

作者信息

Zheng Xin-Rui, Chen Tao, Yang Yue-Fan, Rao Wei, Wang Guan-Ying, Zhang Shan-Hong, Fei Zhou

机构信息

From the Department of Neurosurgery (X-RZ, TC, Y-FY, WR, ZF); Department of Medical affairs and training, Xijing Hospital, Fourth Military Medical University, Xi'an, Shanxi, PR China (G-YW, S-HZ).

出版信息

Medicine (Baltimore). 2015 Jun;94(23):e739. doi: 10.1097/MD.0000000000000739.

Abstract

The aim of this study is to investigate the incidence of unplanned reoperations from all causes due to bleeding in neurosurgical patients. The medical records of patients who received neurosurgical procedures at our hospital were retrospectively reviewed and data of patients who received reoperations were extracted and summarized. A literature review was conducted of the Medline, Cochrane, EMBASE, and Google Scholar databases up to November 2013. The main outcome measure was the rate of unplanned reoperations due to bleeding. At our hospital, 68 patients with a mean age of 41.5 ± 21.5 years (range, 7 months to 76 years) received an unplanned reoperation. More than 70% of the patients were older than 18 years, 64.7% were males, and 94.1% had cranial surgery. Almost 60% of the patients received >1 blood transfusion (58.8%) after the first surgery. Of the 68 patients, 35 (51.5%) received a second operation due to bleeding. Univariate logistic regression analysis only showed that an increasing time interval between the first and second surgery was associated with a decreased chance of the reoperation being performed due to bleeding (odds ratio [OR] = 0.843, 95% confidence interval [CI]: 0.720-0.987; P = .033). Of 229 studies identified, 5 retrospective reports with a total of 1375 patients were included in the analysis. The rate of reoperations for bleeding in the 5 studies ranged from 4.2% to 31.5%. Employing measures to reduce postoperative bleeding may help reduce the rate of unplanned neurosurgical reoperations.

摘要

本研究旨在调查神经外科患者因出血导致的各种原因的非计划再次手术的发生率。对我院接受神经外科手术患者的病历进行回顾性分析,提取并总结接受再次手术患者的数据。截至2013年11月,对Medline、Cochrane、EMBASE和谷歌学术数据库进行了文献综述。主要观察指标为因出血导致的非计划再次手术率。在我院,68例患者接受了非计划再次手术,平均年龄为41.5±21.5岁(范围为7个月至76岁)。超过70%的患者年龄大于18岁,64.7%为男性,94.1%接受了颅脑手术。近60%的患者在首次手术后接受了>1次输血(58.8%)。在这68例患者中,35例(51.5%)因出血接受了二次手术。单因素logistic回归分析仅显示,首次和第二次手术之间的时间间隔增加与因出血进行再次手术的机会降低相关(比值比[OR]=0.843,95%置信区间[CI]:0.720-0.987;P=0.033)。在纳入分析的229项研究中,有5篇回顾性报告,共1375例患者。这5项研究中因出血进行再次手术的发生率在4.2%至31.5%之间。采取措施减少术后出血可能有助于降低神经外科非计划再次手术率。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4804/4616491/0c1b46dd533a/medi-94-e739-g003.jpg

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