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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Fortes Z B, Scivoletto R, Garcia-Leme J

Department of Pharmacology, University of São Paulo, Brazil.

Gen Pharmacol. 1989;20(5):615-20. doi: 10.1016/0306-3623(89)90096-7.

The constrictor response of microvessels to norepinephrine and tyramine, and the dilator response to acetylcholine and papaverine was equivalent in normal and alloxan-induced diabetic rats. 2. Acetylcholine and phentolamine were equally effective as antagonists of the vasoconstrictor action of norepinephrine in both groups of animals. 3. The minimum effective doses of histamine and PAF-acether to produce maximum dilation of microvessels, or to antagonize the response to norepinephrine in normal rats had to be increased 20-fold to evoke equivalent effects in diabetic animals.

在正常大鼠和四氧嘧啶诱导的糖尿病大鼠中，微血管对去甲肾上腺素和酪胺的收缩反应以及对乙酰胆碱和罂粟碱的舒张反应相当。2. 在两组动物中，乙酰胆碱和酚妥拉明作为去甲肾上腺素血管收缩作用的拮抗剂同样有效。3. 在正常大鼠中，产生微血管最大舒张或拮抗去甲肾上腺素反应的组胺和血小板活化因子（PAF-乙酰醚）的最小有效剂量，在糖尿病动物中必须增加20倍才能产生等效作用。

Fortes Z B, Scivoletto R, Garcia-Leme J

Department of Pharmacology, University of São Paulo, Brazil.

Gen Pharmacol. 1989;20(5):615-20. doi: 10.1016/0306-3623(89)90096-7.

The constrictor response of microvessels to norepinephrine and tyramine, and the dilator response to acetylcholine and papaverine was equivalent in normal and alloxan-induced diabetic rats. 2. Acetylcholine and phentolamine were equally effective as antagonists of the vasoconstrictor action of norepinephrine in both groups of animals. 3. The minimum effective doses of histamine and PAF-acether to produce maximum dilation of microvessels, or to antagonize the response to norepinephrine in normal rats had to be increased 20-fold to evoke equivalent effects in diabetic animals.

在正常大鼠和四氧嘧啶诱导的糖尿病大鼠中，微血管对去甲肾上腺素和酪胺的收缩反应以及对乙酰胆碱和罂粟碱的舒张反应相当。2. 在两组动物中，乙酰胆碱和酚妥拉明作为去甲肾上腺素血管收缩作用的拮抗剂同样有效。3. 在正常大鼠中，产生微血管最大舒张或拮抗去甲肾上腺素反应的组胺和血小板活化因子（PAF-乙酰醚）的最小有效剂量，在糖尿病动物中必须增加20倍才能产生等效作用。