Kim Hyung-Keun, Seo Kyung-Jin, Choi Hyun Ho, Kim Sung Soo, Chae Hiun-Suk, Shin Ok-Ran, Ahn Chang Hyuck, Cho Young-Seok
Department of Internal Medicine, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Uijeongbu 480-717, Republic of Korea.
Department of Hospital Pathology, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Uijeongbu 480-717, Republic of Korea.
Gastroenterol Res Pract. 2015;2015:842876. doi: 10.1155/2015/842876. Epub 2015 May 12.
Background/Aim. Serrated polyposis syndrome (SPS) is a rare condition characterized by multiple serrated polyps throughout the colon and rectum. The aim of this study was to evaluate the clinicopathological characteristics of SPS in Koreans. Methods. This retrospective analysis of prospectively collected data was performed using information from the endoscopy, clinical records, and pathology database system of Uijeongbu St. Mary's Hospital. Consecutive patients satisfying the updated 2010 World Health Organization criteria for SPS between June 2011 and May 2014 were enrolled. Results. Of the 17,552 patients who underwent colonoscopies during the study period, 11 (0.06%) met the criteria for SPS. The mean age of these patients was 55.6 years. Ten patients (91%) were males. None had a family history of CRC or a first-degree relative with SPS. Seven patients (64%) had synchronous advanced adenoma. One patient had coexistence of SPS with CRC that was diagnosed at the initial colonoscopy. Five patients (45%) had more than 30 serrated polyps. One of the patients underwent surgery and 10 underwent endoscopic resection. Conclusion. The prevalence of SPS in this study cohort was comparable to that in Western populations. Considering the high risk of CRC, correct diagnosis and careful follow-up for SPS are necessary.
背景/目的。锯齿状息肉病综合征（SPS）是一种罕见疾病，其特征为在整个结肠和直肠出现多个锯齿状息肉。本研究的目的是评估韩国人SPS的临床病理特征。方法。利用议政府圣玛丽医院的内镜检查、临床记录和病理数据库系统中的信息，对前瞻性收集的数据进行回顾性分析。纳入2011年6月至2014年5月期间符合2010年世界卫生组织更新的SPS标准的连续患者。结果。在研究期间接受结肠镜检查的17552例患者中，11例（0.06%）符合SPS标准。这些患者的平均年龄为55.6岁。10例患者（91%）为男性。无一例有结直肠癌家族史或SPS的一级亲属。7例患者（64%）有同步进展性腺瘤。1例患者在初次结肠镜检查时被诊断为SPS与结直肠癌并存。5例患者（45%）有30多个锯齿状息肉。1例患者接受了手术，10例接受了内镜切除。结论。本研究队列中SPS的患病率与西方人群相当。鉴于结直肠癌的高风险，对SPS进行正确诊断和仔细随访是必要的。
