Shimohara Yasutsugu, Urabe Yuji, Oka Shiro, Hisabe Takashi, Yamada Atsushi, Matsushita Hiro-O, Kato Bunichiro, Sakamoto Hirotsugu, Horii Joichiro, Watanabe Daisuke, Eda Hirotsugu, Nakamura Fumika, Chino Akiko, Yamamoto Hironori, Takayama Tetsuji, Matsumoto Takayuki, Ishikawa Hideki, Tanaka Shinji
Department of Gastroenterology and Metabolism, Hiroshima University Hospital, Hiroshima, Japan.
Division of Regeneration and Medicine Center for Translational and Clinical Research, Hiroshima University Hospital, 1-2-3, Kasumi, Minamiku, Hiroshima, 734-8551, Japan.
J Gastroenterol. 2022 Apr;57(4):300-308. doi: 10.1007/s00535-022-01859-7. Epub 2022 Feb 24.
Serrated polyposis syndrome (SPS), a type of colorectal polyposis characterized by multiple serrated polyps, is associated with a high risk of colorectal carcinoma (CRC). This study aimed to clarify the clinicopathological characteristics of SPS in Japan.
We investigated the clinicopathological characteristics of patients with SPS from the "Multicenter Study on Clinicopathological Characteristics of SPS (UMIN 000032138)" by the Colorectal Serrated Polyposis Syndrome (SPS) Study Group. In this study, patients were diagnosed with SPS based on the 2019 World Health Organization (WHO) SPS diagnostic criteria.
Ninety-four patients were diagnosed with SPS in 10 institutions between January 2001 and December 2017. The mean number (± standard deviation [SD]) of resected lesions per patient was 11.3 ± 13.8. The mean age at diagnosis of SPS was 63.3 ± 11.6 years, and 58 patients (61.7%) were male. Eighty-seven (92.6%) and 16 (17.0%) patients satisfied WHO diagnostic criteria I and II, respectively. Nine patients (9.6%) satisfied both criteria I and II. Carcinoma (T1-T4) were observed in 21 patients (22.3%) and 24 lesions. Of the 21 patients with CRC, 19 (90.4%) satisfied diagnostic criterion I, 1 (4.8%) satisfied diagnostic criterion II, and 1 (4.8%) satisfied diagnostic criteria I and II. There was no notable difference in the prevalence of CRC among patients who met diagnostic criterion I, II, and both I and II.
Patients with SPS have a high risk of CRC and should undergo regular surveillance colonoscopy. Raising awareness of this syndrome is crucial.
锯齿状息肉病综合征（SPS）是一种以多发锯齿状息肉为特征的结直肠息肉病，与结直肠癌（CRC）的高风险相关。本研究旨在阐明日本SPS的临床病理特征。
我们通过结直肠锯齿状息肉病综合征（SPS）研究组进行的“SPS临床病理特征多中心研究（UMIN 000032138）”，调查了SPS患者的临床病理特征。在本研究中，患者根据2019年世界卫生组织（WHO）SPS诊断标准被诊断为SPS。
2001年1月至2017年12月期间，10家机构中有94例患者被诊断为SPS。每位患者切除病变的平均数量（±标准差[SD]）为11.3±13.8。SPS诊断时的平均年龄为63.3±11.6岁，58例患者（61.7%）为男性。分别有87例（92.6%）和16例（17.0%）患者符合WHO诊断标准I和II。9例患者（9.6%）同时符合标准I和II。在21例患者（22.3%）和24个病变中观察到癌（T1-T4）。在21例CRC患者中，19例（90.4%）符合诊断标准I，1例（4.8%）符合诊断标准II，1例（4.8%）同时符合诊断标准I和II。符合诊断标准I、II以及同时符合I和II的患者中CRC的患病率没有显著差异。
SPS患者有患CRC的高风险，应定期接受结肠镜检查监测。提高对该综合征的认识至关重要。
