Guo Xu-Guang, Wang Qian, Xia Yong, Zheng Lei
Department of Clinical Laboratory Medicine, The Third Affiliated Hospital of Guangzhou Medical University Guangzhou, Guangdong, People's Republic of China ; Department of Internal Medicine, The Third Clinical College of Guangzhou Medical University Guangzhou, Guangdong, People's Republic of China ; Department of Clinical Laboratory Medicine, Nanfang Hospital of Southern Medical University Guangzhou, Guangdong, People's Republic of China.
Department of Clinical Laboratory Medicine, Nanfang Hospital of Southern Medical University Guangzhou, Guangdong, People's Republic of China.
Int J Clin Exp Med. 2015 Mar 15;8(3):3691-9. eCollection 2015.
The C8092A polymorphism in the ERCC1 (excision repair cross-complementation group 1) gene was shown to be associated with breast carcinoma risk. However, the results of different studies remain controversial. A meta-analysis including 3,308 cases and 3,242 controls from eight studies was performed to explore the association between the C8092A polymorphism in the ERCC1 gene and breast cancer risk. The pooled odds ratios (ORs) and their corresponding 95% confidence intervals (95% CIs) were evaluated by the random effects model. No significant association was detected in an allelic genetic model (OR: 1.081, 95% CI: 0.994-1.175, P=0.068, Pheterogeneity=0.331), a homozygote model (OR: 1.213, 95% CI: 0.926-1.589, P=0.160, Pheterogeneity=0.071), a heterozygote model (OR: 1.061, 95% CI: 0.958-1.176, P=0.256, Pheterogeneity=0.950), a dominant genetic model (OR: 1.082, 95% CI: 0.981-1.193, P=0.113, Pheterogeneity=0.816) and a recessive genetic model (OR: 1.181, 95% CI: 0.904-1.543, P=0.223, Pheterogeneity=0.060) between the C8092A polymorphism in the ERCC1 gene and breast tumor. A significant relationship between the C8092A polymorphism in the ERCC1 gene and breast tumor in Caucasian group was found in a homozygote genetic model (OR: 1.353, 95% CI: 1.009-1.815, P=0.044, Pheterogeneity=0.516) and a recessive genetic model (OR: 1.339, 95% CI: 1.004-1.785, P=0.047, Pheterogeneity=0.532). Individuals with the C8092A polymorphism in the ERCC1 gene have a higher risk of breast cancer in Caucasians, but not for Asians.
ERCC1（切除修复交叉互补组1）基因中的C8092A多态性被证明与乳腺癌风险相关。然而，不同研究的结果仍存在争议。进行了一项荟萃分析，纳入来自八项研究的3308例病例和3242例对照，以探讨ERCC1基因中的C8092A多态性与乳腺癌风险之间的关联。采用随机效应模型评估合并比值比（OR）及其相应的95%置信区间（95%CI）。在等位基因遗传模型（OR：1.081，95%CI：0.994 - 1.175，P = 0.068，P异质性 = 0.331）、纯合子模型（OR：1.213，95%CI：0.926 - 1.589，P = 0.160，P异质性 = 0.071）、杂合子模型（OR：1.061，95%CI：0.958 - 1.176，P = 0.256，P异质性 = 0.950）、显性遗传模型（OR：1.082，95%CI：0.981 - 1.193，P = 0.113，P异质性 = 0.816）和隐性遗传模型（OR：1.181，95%CI：0.904 - 1.543，P = 0.223，P异质性 = 0.060）中，均未检测到ERCC1基因中的C8092A多态性与乳腺肿瘤之间存在显著关联。在纯合子遗传模型（OR：1.353，95%CI：1.009 - 1.815，P = 0.044，P异质性 = 0.516）和隐性遗传模型（OR：1.339，95%CI：1.004 - 1.785，P = 0.047，P异质性 = 0.532）中，发现ERCC1基因中的C8092A多态性与白种人群体中的乳腺肿瘤存在显著关系。ERCC1基因中具有C8092A多态性的个体在白种人中患乳腺癌的风险较高，但在亚洲人中并非如此。
