Department of Genetics, Washington University School of Medicine, St. Louis, Missouri.
Department of Surgery, University of Utah School of Medicine, Salt Lake City, Utah.
Fertil Steril. 2018 Jan;109(1):20-26. doi: 10.1016/j.fertnstert.2017.10.028.
Recent epidemiological studies have identified an association between male factor infertility and increased cancer risk, however, the underlying etiology for the shared risk has not been investigated. It is likely that much of the association between the two disease states can be attributed to underlying genetic lesions. In this article we review the reported associations between cancer and spermatogenic defects, and through database searches we identify candidate genes and gene classes that could explain some of the observed shared genetic risk. We discuss the importance of fully characterizing the genetic basis for the relationship between cancer and male factor infertility and propose future studies to that end.
最近的流行病学研究已经确定了男性因素不孕与癌症风险增加之间的关联，然而，这种共同风险的潜在病因尚未得到研究。很可能这两种疾病状态之间的大部分关联都可以归因于潜在的遗传病变。在本文中，我们回顾了癌症和精子发生缺陷之间的报道关联，并通过数据库搜索确定了可能解释一些观察到的共同遗传风险的候选基因和基因类别。我们讨论了充分描述癌症和男性因素不孕之间关系的遗传基础的重要性，并提出了为此目的的未来研究。
