Haddad Peiman, Shazadi Sohrab, Samiei Farhad, Kharrazi Homayoun Hadizadeh, Tabatabaeefar Morteza, Rakhsha Afshin, Faranoosh Mohammad, Torabi-Nami Mohammad, Dadras Ali, Liaghi Atieh, Nafarieh Leila
Cancer Institute, Department of Radiation Oncology, School of Medicine, Tehran University of Medical Sciences Tehran, Iran.
Department of Neurosurgery, School of Medicine, Shahid Beheshti University of Medical Sciences Tehran, Iran.
Int J Clin Exp Med. 2015 Mar 15;8(3):3946-55. eCollection 2015.
Research and practice of neuro-oncology compiles clinical neuroscience expertise from neurosurgery, radiation oncology, neuroradiology, medical oncology, neuropathology and related disciplines to optimize planning and therapy in central nervous system malignancies. Such an interdisciplinary context prompted health-care providers from all related disciplines to establish the Neuro-Oncology Scientific Club (NOSC) in Iran and let it flourish since 3 years ago. With the advent of advanced technologies and through continued share of experience, NOSC members have tried to provide more integrated diagnoses and therapeutic care to brain tumor patients across the country. NOSC activities revolve around some key tenets including dissemination of education and updates, facilitation of institutional collaborations; data registry and patients' awareness. By virtue of recent insights on molecular characterization of brain tumors such as codeletion of chromosomes 1p and 19q in anaplastic gliomas and O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation in glioblastoma, a range of translational research is being followed within NOSC. The most recent NOSC meeting which was held in Tehran, recapitulated main advances and dealt with the current debates on functional neurosurgery, biological markers and neuroimaging, risk prediction models in high grade gliomas and clinical issues in pediatric neuro-oncology. This article gives an overview of current hotspots in neuro-oncology research and practice which are pursued within NOSC.
神经肿瘤学的研究与实践汇集了神经外科、放射肿瘤学、神经放射学、医学肿瘤学、神经病理学及相关学科的临床神经科学专业知识，以优化中枢神经系统恶性肿瘤的治疗规划和治疗方案。这种跨学科背景促使伊朗所有相关学科的医疗服务提供者成立了神经肿瘤学科学俱乐部（NOSC），并且自三年前以来一直蓬勃发展。随着先进技术的出现以及经验的持续分享，NOSC成员一直努力为全国的脑肿瘤患者提供更综合的诊断和治疗护理。NOSC的活动围绕一些关键原则展开，包括教育和最新信息的传播、促进机构间合作、数据登记以及患者宣传。鉴于最近对脑肿瘤分子特征的认识，如间变性胶质瘤中1p和19q染色体的共缺失以及胶质母细胞瘤中O6-甲基鸟嘌呤-DNA甲基转移酶（MGMT）启动子甲基化，NOSC正在开展一系列转化研究。最近在德黑兰举行的NOSC会议总结了主要进展，并讨论了当前关于功能神经外科、生物标志物和神经影像学、高级别胶质瘤的风险预测模型以及小儿神经肿瘤学临床问题的争论。本文概述了NOSC所开展的神经肿瘤学研究与实践中的当前热点问题。
