Chen S-D, Hou P-F, Lou L, Jin X, Wang T-H, Xu J-L
Department of Neurosurgery, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang, China.
Eur Rev Med Pharmacol Sci. 2014 Jul;18(13):1904-9.
This work intends to quantitatively analyze on pathological grade of glioma using Magnetic Resonance (MR) diffusion weighted imaging (DWI) and exploring the relativity of pathological grade and Apparent Diffusion Coefficient (ADC) value of MR diffusion weighted imaging.
40 patients with glioma accepted the MR diffusion weighted imaging to measure the ADC value of tumor with 3.0T MR machine before the surgery. Tumor samples were sent for pathologic diagnosis and tumor cell density measurement after the operation. The acquired data were analyzed statistically.
The ADC values of low-grade (WHO I-II) glioma were higher than that of high-grade (WHO III-IV), but the cell density of low-grade glioma was apparently lower than that of high-grade glioma. The ADC values and density of tumor cells were negatively correlated with WHO malignant grades, while the density of cells of glioma was positively correlated with WHO malignant grades.
MR diffusion weighted imaging is an objective and effective examination method.
本研究旨在利用磁共振（MR）扩散加权成像（DWI）对胶质瘤的病理分级进行定量分析，并探讨MR扩散加权成像的病理分级与表观扩散系数（ADC）值之间的相关性。
40例胶质瘤患者在手术前行3.0T MR机MR扩散加权成像以测量肿瘤的ADC值。术后将肿瘤样本送检进行病理诊断及肿瘤细胞密度测定。对所获数据进行统计学分析。
低级别（WHO I-II级）胶质瘤的ADC值高于高级别（WHO III-IV级），但低级别胶质瘤的细胞密度明显低于高级别胶质瘤。肿瘤细胞的ADC值和密度与WHO恶性分级呈负相关，而胶质瘤的细胞密度与WHO恶性分级呈正相关。
MR扩散加权成像是一种客观有效的检查方法。
