Song Jun, Yin Jieyun, Chen Jiande
Division of Gastroenterology, University of Texas Medical Branch Galveston, Texas ; Department of Gastroenterology, Wuhan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan, Hubei, China.
Division of Gastroenterology, University of Texas Medical Branch Galveston, Texas.
Int J Clin Exp Med. 2015 Mar 15;8(3):4635-46. eCollection 2015.
This study was designed to compare the effects and mechanisms of transcutaneous electroacupuncture (TEA) on rectal distention (RD)-induced intestinal dysmotility with EA.
six female dogs chronically implanted with a duodenal fistula, a proximal colon fistula and intestinal serosal electrodes were studied. EA and TEA were performed via needles and cutaneous electrodes placed at bilateral ST-36 (Zusanli) acupoints respectively; their effects on postprandial intestinal dysmotility (slow waves, contractions and transit) induced by RD, and autonomic functions were compared.
RD at a volume of 140 ml suppressed intestinal contractions; the motility index was reduced with RD (P = 0.001). Both EA and TEA ameliorated the suppressed contractions (P = 0.003 and 0.001) and their effects were comparable. RD reduced the percentage of normal intestinal slow waves (P = 0.002) that was increased with both EA and TEA (P = 0.005 and 0.035). No significant difference was noted between EA and TEA. EA and TEA reduced small bowel transit time (P = 0.001 and 0.007); these prokinetic effects were blocked by atropine. Both EA and TEA increased vagal activity assessed by the spectral analysis of heart rate variability (both P = 0.03).
RD inhibits postprandial intestinal motility. Both EA and TEA at ST-36 are able to improve the RD-induced impairment in intestinal contractions, transit and slow waves mediated via the vagal mechanism. Needleless TEA is as effective as EA in ameliorating the intestinal hypomotility.
本研究旨在比较经皮电针（TEA）与电针（EA）对直肠扩张（RD）诱导的肠道运动障碍的影响及机制。
对6只长期植入十二指肠瘘、近端结肠瘘和肠浆膜电极的雌性犬进行研究。分别通过置于双侧足三里（ST-36）穴位的针和皮肤电极进行电针和经皮电针治疗；比较它们对RD诱导的餐后肠道运动障碍（慢波、收缩和转运）以及自主神经功能的影响。
140毫升容量的RD抑制肠道收缩；RD使运动指数降低（P = 0.001）。电针和经皮电针均改善了受抑制的收缩（P = 0.003和0.001），且它们的效果相当。RD降低了正常肠道慢波的百分比（P = 0.002），电针和经皮电针均使其增加（P = 0.005和0.035）。电针和经皮电针之间未观察到显著差异。电针和经皮电针缩短了小肠转运时间（P = 0.001和0.007）；这些促动力作用被阿托品阻断。通过心率变异性频谱分析评估，电针和经皮电针均增加了迷走神经活动（均P = 0.03）。
RD抑制餐后肠道运动。双侧足三里的电针和经皮电针均能改善RD诱导的肠道收缩、转运和慢波的损害，其通过迷走神经机制介导。无针经皮电针在改善肠道运动减弱方面与电针同样有效。
