Walsh J T, Deutsch T F
IEEE Trans Biomed Eng. 1989 Dec;36(12):1195-201. doi: 10.1109/10.42114.
The ablation rate of guinea pig skin and bovine aorta, myocardium, and liver by a CO2 laser emitting 2-microseconds-long pulses was quantified. Ablation efficiency was found to be strongly dependent upon the ultimate tensile strength of the tissue; the ablation efficiency of liver is seven times that of skin. Gluteraldehyde cross linking of skin, which is known to greatly increase tissue stiffness but not significantly affect ultimate tensile strength, did not change the ablation rate. The water content of the tissues, which largely determines the optical and thermal properties, was measured and found to vary only slightly. The results demonstrate that tissue mechanical properties are important in the interpretation and modeling of pulsed laser ablation of tissue and that variations in these mechanical properties can lead to drastically different cutting rates for different tissues.
对发射2微秒长脉冲的二氧化碳激光对豚鼠皮肤、牛主动脉、心肌和肝脏的消融速率进行了量化。发现消融效率强烈依赖于组织的极限抗拉强度；肝脏的消融效率是皮肤的七倍。已知戊二醛交联皮肤可大大增加组织硬度，但对极限抗拉强度影响不大，却并未改变消融速率。测量了在很大程度上决定光学和热学性质的组织含水量，发现其变化很小。结果表明，组织力学性质在脉冲激光组织消融的解释和建模中很重要，并且这些力学性质的变化会导致不同组织的切割速率有极大差异。
