Ross E V, Domankevitz Y, Skrobal M, Anderson R R
Wellman Laboratories of Photomedicine, Department of Dermatology, Massachusetts General Hospital, Boston 02114, USA.
Lasers Surg Med. 1996;19(2):123-9. doi: 10.1002/(SICI)1096-9101(1996)19:2<123::AID-LSM1>3.0.CO;2-U.
Resurfacing with the CO2 laser is rapidly gaining acceptance for skin rejuvenation. Advances in CO2 laser and scanning technology allow for precise tissue removal with minimal thermal damage. High energy CO2 laser pulses have been widely used effectively to smooth the surface of facial skin; however, pulse duration effects on ablation and thermal damage have not been systematically studied over the milli-second region (0.25-10 ms).
STUDY DESIGN/MATERIALS AND METHODS: This study characterizes the ablation threshold, heat of ablation, and residual thermal damage in skin resulting from CO2 laser pulses with a Gaussian beam profile. Mass loss from fresh pig skin was measured with an analytical balance, and residual thermal damage was determined through histology.
Pulse durations > 1 ms were associated with higher ablation thresholds and localized increased thermal damage.
Our results show that although pulse duration is an important determinant in ablation and thermal damage, irradiance is more critical as an independent parameter in predicting the effects of CO2 laser pulses.
二氧化碳激光换肤术在皮肤年轻化治疗中迅速获得认可。二氧化碳激光和扫描技术的进步使得能够在热损伤最小的情况下精确去除组织。高能二氧化碳激光脉冲已被广泛有效地用于使面部皮肤表面光滑；然而，在毫秒区域（0.25 - 10毫秒）内，脉冲持续时间对消融和热损伤的影响尚未得到系统研究。
研究设计/材料与方法：本研究对高斯光束轮廓的二氧化碳激光脉冲在皮肤中产生的消融阈值、消融热和残余热损伤进行了表征。用分析天平测量新鲜猪皮的质量损失，并通过组织学确定残余热损伤。
脉冲持续时间>1毫秒与更高的消融阈值和局部热损伤增加有关。
我们的结果表明，虽然脉冲持续时间是消融和热损伤的重要决定因素，但在预测二氧化碳激光脉冲的效果时，辐照度作为一个独立参数更为关键。
